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Effect Of Rolling On Viscoelastic Fluids Using A Novel Testing Device, Aswini Mangadu
Effect Of Rolling On Viscoelastic Fluids Using A Novel Testing Device, Aswini Mangadu
Dissertations and Theses
The purpose of this research thesis project was to develop a mechanical testing device that could enable us to load articular cartilage with a rolling/sliding motion. This novel device was then used to observe the effect of a rolling motion on the fluid film thickness of different lubricants (motor oil, synovial fluid and Hyaluronic Acid (HA)) to varying loads (1kg, 2,kg, 3kg and 4kg) and speeds (10, 25, 48 and 91 mm/s) applied on the sample fluids for 10 cycles. We were able to examine the effect of different speeds within each load for each of the fluid that was …
Development Of An Approach To Increase Drug Uptake To Bone Tumors Using Non-Invasive Mechanical Loading, Paolo E. Palacio
Development Of An Approach To Increase Drug Uptake To Bone Tumors Using Non-Invasive Mechanical Loading, Paolo E. Palacio
Dissertations and Theses
This thesis develops an approach to enhance drug delivery to bone tumors by implementing a non-invasive mechanical loading technique. An imaging protocol that characterizes the load-enhanced drug uptake is also presented. The long-term goal of this work is to develop a clinical protocol that enhances the delivery of therapeutic agents to bone tumors by utilizing load-bearing activity. This easy-to-implement approach could help increase drug uptake into the tumor interstitial fluid space as well as into tumor cells, thereby enhancing a drug's clinical effect while decreasing systemic drug dosage and unwanted side effects. This thesis details the process used to grow …