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Post-Cmos Fabrication Of Working Electrodes For On-Chip Recordings Of Transmitter Release, Sunitha Ayers, Khajak Berberian, Kevin Gillis, Manfred Lindau, Bradley Minch

Bradley Minch

The release of neurotransmitters and hormones from secretory vesicles plays a fundamental role in the function of the nervous system including neuronal communication. High-throughput testing of drugs modulating transmitter release is becoming an increasingly important area in the fields of cell biology, neurobiology, and neurology. Carbon-fiber amperometry provides high-resolution measurements of amount and time course of the transmitter release from single vesicles, and their modulation by drugs and molecular manipulations. However, these methods do not enable the rapid collection of data from a large number of cells. To allow this testing, we have developed a complementary metal-oxide semiconductor (CMOS) potentiostat …