Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Identification Of Hemodynamically Optimal Coronary Stent Designs Based On Vessel Caliber, Timothy J. Gundert, Alison L. Marsden, Weiguang Yang, David S. Marks, John F. Ladisa
Identification Of Hemodynamically Optimal Coronary Stent Designs Based On Vessel Caliber, Timothy J. Gundert, Alison L. Marsden, Weiguang Yang, David S. Marks, John F. Ladisa
Biomedical Engineering Faculty Research and Publications
Coronary stent design influences local patterns of wall shear stress (WSS) that are associated with neointimal growth, restenosis, and the endothelialization of stent struts. The number of circumferentially repeating crowns NC for a given stent de- sign is often modified depending on the target vessel caliber, but the hemodynamic implications of altering NC have not previously been studied. In this investigation, we analyzed the relationship between vessel diameter and the hemodynamically optimal NC using a derivative-free optimization algorithm coupled with computational fluid dynamics. The algorithm computed the optimal vessel diameter, defined as minimizing the area of stent-induced …