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Transdermal Drug Delivery Systems: Analysis Of Adhesion Failure, Zachary Brooks, Tushar Goswami, Amy Neidhard-Doll, Tarun Goswami
Transdermal Drug Delivery Systems: Analysis Of Adhesion Failure, Zachary Brooks, Tushar Goswami, Amy Neidhard-Doll, Tarun Goswami
Biomedical, Industrial & Human Factors Engineering Faculty Publications
The most critical component of the TDDS is the adhesive, which is responsible for the safety, efficacy and quality of the patch. For drug delivery to successfully occur, the patch must adhere to the surface of the contact area. If a patch has inadequate adhesion, it is likely to fall off before the entire delivery period has been satisfied, leading to risks for the patient and others who may encounter the patch. Despite the critical concerns associated with the adhesive properties of the patches, the adhesion quality and failure mechanisms have not been fully studied. If certain molecules encounter the …