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- Asthma (1)
- Asthma; inhaler; adherence; clinical outcomes (1)
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- Controlled (1)
- Coronary artery disease (1)
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- Hypoxia (1)
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- Inhaled corticosteroid (1)
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- Poisson distribution; age; asthma exacerbations; body mass index; decision support systems; decision-support system; diseases; dose counter adherence; gender; inhaler medication; multisite longitudinal randomised control trial; multivariate modified Poisson regression; patient monitoring; pneumodynamics; regression analysis; remote monitoring adherence device; respiratory medicine; univariate modified Poisson regression (1)
- Severe exacerbations (1)
- Shear control (1)
- SpearChips (1)
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Articles 1 - 6 of 6
Full-Text Articles in Engineering
Enhanced Corrosion Protection And Biocompatibility Of A Plga-Silane Coating On Az31 Mg Alloy For Orthopaedic Applications, Sankalp Agarwal, Muhammad Morshed, Marie-Noelle Labour, David Hoey, Brendan Duffy, James Curtin, Swarna Jaiswal
Enhanced Corrosion Protection And Biocompatibility Of A Plga-Silane Coating On Az31 Mg Alloy For Orthopaedic Applications, Sankalp Agarwal, Muhammad Morshed, Marie-Noelle Labour, David Hoey, Brendan Duffy, James Curtin, Swarna Jaiswal
Articles
This paper reports a multi-step procedure to fabricate a novel corrosion resistant and biocompatible PLGA-silane coating on the magnesium (Mg) alloy AZ31. The first step involves alkaline passivation followed by dip coating in a methyltriethoxysilane (MTES) and tetraethoxysilane (TEOS) mixture to produce a cross-linked siloxane coating. The second step is to impart an amine functionalization to the silane modified surface by using 3-aminopropyl-triethoxy silane (APTES) for promoting adhesion of the acid terminated poly-(lactic-co-glycolic) acid (PLGA) as a final coating step. Static contact angle measurements, Fourier transform infrared spectroscopy and scanning electron microscopy analysis confirmed the successful assembly of coatings on …
A Method To Calculate Adherence To Inhaled Therapy That Reflects The Changes In Clinical Features Of Asthma, Imran Sulaiman, Jansen Seheult, Elaine Machale, Fiona Boland, Susan M. O’Dwyer, Viliam Rapcan, Shona D’Arcy, Breda Cushen, Matshediso Mokoka, Isabelle Killane, Sheila A. Ryder, Richard B. Reilly, Richard W. Costello
A Method To Calculate Adherence To Inhaled Therapy That Reflects The Changes In Clinical Features Of Asthma, Imran Sulaiman, Jansen Seheult, Elaine Machale, Fiona Boland, Susan M. O’Dwyer, Viliam Rapcan, Shona D’Arcy, Breda Cushen, Matshediso Mokoka, Isabelle Killane, Sheila A. Ryder, Richard B. Reilly, Richard W. Costello
Articles
Electronic monitors are considered the gold standard for objectively quantifying adherence to inhaled therapy (1). Most studies using electronic recording devices have reported adherence as the mean adherence, or the mean daily dose, over the study period (2–4). However, this method does not reflect variations in the way that patients use their treatments. For example, the mean adherence is the same whether an individual took the medication according to the prescribed schedule or took all the doses in the first half of a dosing period, leaving none in the second half. Inhaler technique must …
Predicting Asthma Exacerbations Employing Remotely Monitored Adherence, Isabelle Killane, Imran Sulaiman, Elaine Mac Hale, Aoife Breathnach, Terrence Taylor, Martin Holmes, Richard B Reilly, Richard W Costello
Predicting Asthma Exacerbations Employing Remotely Monitored Adherence, Isabelle Killane, Imran Sulaiman, Elaine Mac Hale, Aoife Breathnach, Terrence Taylor, Martin Holmes, Richard B Reilly, Richard W Costello
Articles
This Letter investigated the efficacy of a decision-support system, designed for respiratory medicine, at predicting asthma exacerbations in a multi-site longitudinal randomised control trial. Adherence to inhaler medication was acquired over 3 months from patients with asthma employing a dose counter and a remote monitoring adherence device which recorded participant's inhaler use: n = 184 (23,656 audio files), 61% women, age (mean ± sd) 49.3 ± 16.4. Data on occurrence of exacerbations was collected at three clinical visits, 1 month apart. The relative risk of an asthma exacerbation for those with good and poor adherence was examined employing a univariate …
A Protocol For A Randomised Clinical Trial Of The Effect Of Providing Feedback On Inhaler Technique And Adherence From An Electronic Device In Patients With Poorly Controlled Severe Asthma, Imran Sulaiman, Martin Holmes, Shona D'Arcy, Viliam Rapčan, Desmond Michael Murphy, Gloria Crispino, Isabelle Killane, Rw Costello, Richard B Reilly, Jansen Seheult, Gregory Diette, Elaine Machale, Terence Taylor
A Protocol For A Randomised Clinical Trial Of The Effect Of Providing Feedback On Inhaler Technique And Adherence From An Electronic Device In Patients With Poorly Controlled Severe Asthma, Imran Sulaiman, Martin Holmes, Shona D'Arcy, Viliam Rapčan, Desmond Michael Murphy, Gloria Crispino, Isabelle Killane, Rw Costello, Richard B Reilly, Jansen Seheult, Gregory Diette, Elaine Machale, Terence Taylor
Articles
ntroduction In clinical practice, it is difficult to distinguish between patients with refractory asthma from those with poorly controlled asthma, where symptoms persist due to poor adherence, inadequate inhaler technique or comorbid diseases. We designed an audio recording device which, when attached to an inhaler, objectively identifies the time and technique of inhaler use, thereby assessing both aspects of adherence. This study will test the hypothesis that feedback on these two aspects of adherence when passed on to patients improves adherence and helps clinicians distinguish refractory from difficult-to-control asthma. Methods This is a single, blind, prospective, randomised, clinical trial performed …
Oxygen Mass Transport In Stented Coronary Arteries, Eoin Murphy, Adrian S. Dunne, David Martin, Fergal Boyle
Oxygen Mass Transport In Stented Coronary Arteries, Eoin Murphy, Adrian S. Dunne, David Martin, Fergal Boyle
Articles
Oxygen deficiency, known as hypoxia, in arterial walls has been linked to increased intimal hyperplasia, which is the main adverse biological process causing in-stent restenosis. Stent implantation has significant effects on the oxygen transport into the arterial wall. Elucidating these effects is critical to optimizing future stent designs. In this study the most advanced oxygen transport model developed to date was assessed in two test cases and used to compare three coronary stent designs. Additionally, the predicted results from four simplified blood oxygen transport models are compared in the two test cases. The advanced model showed good agreement with experimental …
Self-Powered Microfluidic Device For Rapid Assay Of Antiplatelet Drugs, Bincy Jose, Peter Mccluskey, Niamh Gilmartin, Martin Somers, Dermot Kenny, Antonio J. Ricco, Nigel Kent, Lourdes Basabe-Desmonts
Self-Powered Microfluidic Device For Rapid Assay Of Antiplatelet Drugs, Bincy Jose, Peter Mccluskey, Niamh Gilmartin, Martin Somers, Dermot Kenny, Antonio J. Ricco, Nigel Kent, Lourdes Basabe-Desmonts
Articles
We report the development of a microfluidic device for the rapid assay in whole blood of platelet-protein interactions indicative of the efficacy of antiplatelet drugs—e.g., aspirin and Plavix, two of the world’s most widely used drugs—in cardiovascular patients. Because platelet adhesion to surface-confined protein matrices is modulated by fluid shear rates at the blood/protein interface, and because such binding is a better indicator of platelet function than platelet self-aggregation, we designed, fabricated, and characterized the performance of a family of disposable, self-powered microfluidic chips with well-defined flow and interfacial shear rates suitable for small blood volumes (≤ 200 µL). We …