Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
Electrospinning Of Core-Shell Collagen Nanofibers, Ying Li
Electrospinning Of Core-Shell Collagen Nanofibers, Ying Li
Electronic Thesis and Dissertation Repository
In tissue engineering, the scaffold plays a critical role in guiding and supporting cells to function and grow optimally. The electrospun nanofibrous scaffold can serve as a near ideal substrate for tissue engineering because it has high surface area and the three-dimensional interconnected porous network can enhance cell attachment and proliferation. Core-shell nanofibrous scaffolds produced with coaxial electrospinning allow bioactive molecule encapsulation to improve cell adhesion, mediate and promote the proper signaling among the cells for their functioning and growth. In the current study, core-shell collagen nanofibers were fabricated via coaxial electrospinning with horizontal and vertical configurations. Core-shell nanofibers with …
Controlled Delivery Of Serp-1 Protein From Poly(Vinyl Alcohol) Hydrogel, Karen L. Kennedy
Controlled Delivery Of Serp-1 Protein From Poly(Vinyl Alcohol) Hydrogel, Karen L. Kennedy
Electronic Thesis and Dissertation Repository
Poly(vinyl alcohol) (PVA) was selected and evaluated as a controlled drug delivery matrix for Serp-1, a potential new therapeutic with anti-inflammatory properties for control of restenosis. PVA hydrogels, containing a high water content, can be formed by physical crosslinking via a process involving freezing and thawing the material in multiple cycles. PVA, being a well known biomaterial, is suited for biomedical applications and the high water content and hydrophilicity provides a friendly environment for the delivery of large protein based drugs. Using bovine serum albumin (BSA) as a model protein, the controlled release properties of PVA were investigated. Release profiles …