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Extracellular Matrix-Derived Microcarriers As 3-D Cell Culture Platforms, Anna Kornmuller
Extracellular Matrix-Derived Microcarriers As 3-D Cell Culture Platforms, Anna Kornmuller
Electronic Thesis and Dissertation Repository
Recognizing the cell-instructive capacity of tissue-specific extracellular matrix (ECM) to direct cell attachment, proliferation and differentiation, there is a need for the development of in vitro cell culture models that reflect the complexity of the ECM to improve stem/progenitor cell expansion and lineage-commitment. This thesis focused on the development and characterization of ECM-derived microcarriers for the in vitro dynamic culture and expansion of stromal cells for cell therapy and tissue engineering applications.
To develop novel platforms for use in dynamic culture systems, initial work focused on applying electrospraying techniques to fabricate microcarriers from decellularized dermal tissue (DDT) and decellularized myocardial …