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Articles 1 - 3 of 3
Full-Text Articles in Engineering
Investigation Of Human Adipose-Derived Stem-Cell Behavior Using A Cell-Instructive Polydopamine-Coated Gelatin-Alginate Hydrogel., Settimio Pacelli, Aparna R Chakravarti, Saman Modaresi, Siddharth Subham, Kyley Burkey, Cecilia Kurlbaum, Madeline Fang, Christopher A Neal, Adam J Mellott, Aishik Chakraborty, Arghya Paul
Investigation Of Human Adipose-Derived Stem-Cell Behavior Using A Cell-Instructive Polydopamine-Coated Gelatin-Alginate Hydrogel., Settimio Pacelli, Aparna R Chakravarti, Saman Modaresi, Siddharth Subham, Kyley Burkey, Cecilia Kurlbaum, Madeline Fang, Christopher A Neal, Adam J Mellott, Aishik Chakraborty, Arghya Paul
Chemical and Biochemical Engineering Publications
Hydrogels can be fabricated and designed to exert direct control over stem cells' adhesion and differentiation. In this study, we have investigated the use of polydopamine (pDA)-treatment as a binding platform for bioactive compounds to create a versatile gelatin-alginate (Gel-Alg) hydrogel for tissue engineering applications. Precisely, pDA was used to modify the surface properties of the hydrogel and better control the adhesion and osteogenic differentiation of human adipose-derived stem cells (hASCs). pDA enabled the adsorption of different types of bioactive molecules, including a model osteoinductive drug (dexamethasone) as well as a model pro-angiogenic peptide (QK). The pDA treatment efficiently retained …
Exploiting The Role Of Nanoparticles For Use In Hydrogel-Based Bioprinting Applications: Concept, Design, And Recent Advances, Aishik Chakraborty, Avinava Roy, Shruthi Polla Ravi, Arghya Paul
Exploiting The Role Of Nanoparticles For Use In Hydrogel-Based Bioprinting Applications: Concept, Design, And Recent Advances, Aishik Chakraborty, Avinava Roy, Shruthi Polla Ravi, Arghya Paul
Chemical and Biochemical Engineering Publications
Three-dimensional (3D) bioprinting is an emerging tissue engineering approach that aims to develop cell or biomolecule-laden, complex polymeric scaffolds with high precision, using hydrogel-based “bioinks”. Hydrogels are water-swollen, highly crosslinked polymer networks that are soft, quasi-solid, and can support and protect biological materials. However, traditional hydrogels have weak mechanical properties and cannot retain complex structures. They must be reinforced with physical and chemical manipulations to produce a mechanically resilient bioink. Over the past few years, we have witnessed an increased use of nanoparticles and biological moiety-functionalized nanoparticles to fabricate new bioinks. Nanoparticles of varied size, shape, and surface chemistries can …
Harnessing The Physicochemical Properties Of Dna As A Multifunctional Biomaterial For Biomedical And Other Applications, Aishik Chakraborty, Shruthi Polla Ravi, Yasmeen Shamiya, Caroline Cui, Arghya Paul
Harnessing The Physicochemical Properties Of Dna As A Multifunctional Biomaterial For Biomedical And Other Applications, Aishik Chakraborty, Shruthi Polla Ravi, Yasmeen Shamiya, Caroline Cui, Arghya Paul
Chemical and Biochemical Engineering Publications
The biological purpose of DNA is to store, replicate, and convey genetic information in cells. Progress in molecular genetics have led to its widespread applications in gene editing, gene therapy, and forensic science. However, in addition to its role as a genetic material, DNA has also emerged as a nongenetic, generic material for diverse biomedical applications. DNA is essentially a natural biopolymer that can be precisely programed by simple chemical modifications to construct materials with desired mechanical, biological, and structural properties. This review critically deciphers the chemical tools and strategies that are currently being employed to harness the nongenetic functions …