Engineering Commons^™

Registration Of In-Vivo To Ex-Vivo Mri Of Surgically Resected Specimens: A Pipeline For Histology To In-Vivo Registration., Maged Goubran, Sandrine De Ribaupierre, Robert R Hammond, Catherine Currie, Jorge G Burneo, Andrew G Parrent, Terry M Peters, Ali R Khan

Robarts Imaging Publications

BACKGROUND: Advances in MRI have the potential to improve surgical treatment of epilepsy through improved identification and delineation of lesions. However, validation is currently needed to investigate histopathological correlates of these new imaging techniques. The purpose of this work is to develop and evaluate a protocol for deformable image registration of in-vivo to ex-vivo resected brain specimen MRI. This protocol, in conjunction with our previous work on ex-vivo to histology registration, completes a registration pipeline for histology to in-vivo MRI, enabling voxel-based validation of novel and existing MRI techniques with histopathology.

NEW METHOD: A combination of image-based and landmark-based 3D …

Quantitative Relaxometry And Diffusion Mri For Lateralization In Mts And Non-Mts Temporal Lobe Epilepsy., Ali R Khan, Maged Goubran, Sandrine De Ribaupierre, Robert R Hammond, Jorge G Burneo, Andrew G Parrent, Terry M Peters

Robarts Imaging Publications

We developed novel methodology for investigating the use of quantitative relaxometry (T1 and T2) and diffusion tensor imaging (DTI) for lateralization in temporal lobe epilepsy. Patients with mesial temporal sclerosis confirmed by pathology (N=8) and non-MTS unilateral temporal lobe epilepsy (N=6) were compared against healthy controls (N=19) using voxel-based analysis restricted to the anterior temporal lobes, and laterality indices for each MRI metric (T1, T2, fractional anisotropy (FA), mean diffusivity, axial and radial diffusivities) were computed based on the proportion of significant voxels on each side. The diffusivity metrics were the most lateralizing MRI metrics in MTS and non-MTS subsets, …