Engineering Commons^™

Knee Articular Cartilage Quantitative Mri Reliability And Left-To-Right And Visit-To-Visit Repeatability In Healthy Subjects Under Compressive Loading, Andrew Borah

Graduate College Dissertations and Theses

Purpose: Quantitative magnetic resonance imaging (qMRI) metrics, including T1ρ and T2*, exhibit considerable promise as image-based biomarkers to monitor the progression of osteoarthritis and post traumatic osteoarthritis. The potential for tracking disease progression utilizing these metrics may be further enhanced with the joint under loaded conditions, as an abnormal response to loading may contribute to cartilage degeneration. Reliability and repeatability studies for T1ρ and T2* measurements have yielded variable results, compared surgical to non- surgical knees, employed diverse sample regions of interest, and acquired images under traditional non-weight bearing knee conditions. The purposes of this study are to quantify side-to-side …