Engineering Commons^™

Mechanobiology Of Breast Cancer Cells, Shea Thompson

UCARE Research Products

Mechanobiology Cells response to mechanical loading Mechanical loading includes Shear flow, Stretching, Compression

How does shear flow effect breast cancer cell migration in a three dimensional space?

By going through the engineering cycle, I was able to successfully convert the Parallel Flow Chamber into a Three Dimensional Flow Chamber. At this point, I have no results due to the COVID-19 outbreak.

Future Research Understanding how breast cancer migrates is essential to preventing the spread of cancer. While other chemical means have been investigated, mechanotransduction is relatively unexplored. Next step: Mechanobiology of breast cancer cells moving through a maze Cells have …

Design Of Tapered Augers For Uniform Unloading Particulate Material From Rectangular Cross-Section Containers, M. S. Burr, Michael F. Kocher, David D. Jones

Biological Systems Engineering: Papers and Publications

The design equation for an auger to provide uniform unloading of particulate material from a container with a rectangular cross-section (Jones and Kocher, 1995) was revised to account for the minimum flighting height that could effectively unload particles with a known average smallest diameter. A minimum flighting height that was about 64% of the average smallest diameter of the particles was experimentally determined to obtain mean slopes of the top surface of the material not significantly different from zero for screened soybeans. A linear taper that best fit the square root curve for the inside diameter of the auger was …

Auger Design For Uniform Unloading Of Granular Material: I. Rectangular Cross-Section Containers, David D. Jones, Michael F. Kocher

Biological Systems Engineering: Papers and Publications

Design equations were developed for two auger configurations that for practical purposes generate uniform vertical flow of granular material through containers or boxes having a rectangular cross-section. Both configurations have uniform outside diameters so the simple geometry of the conventional U-trough housings could be used with these augers. One configuration had a uniform pitch for the auger flighting and decreasing inside diameter. The other had a uniform inside diameter and a decreasing pitch of the flighting with distance from the outlet end of the auger. Both configurations dramatically improved the uniformity of flow over the conventional auger. However, confidence intervals …

Auger Design For Uniform Unloading Of Granular Material: Ii. Cylindrical Containers, Michael F. Kocher, David D. Jones

Biological Systems Engineering: Papers and Publications

The analysis presented can be used to determine the design equations for augers that produce uniform vertical flow of granular material through containers with cylindrical cross-sections. The augers so designed have a constant outside diameter and a variable root or shaft diameter. Installed in cylindrical grain bins they could be used to convert a batch-in-bin dryer to a continuous flow dryer. The analysis is an extension of the work of Jones and Kocher (1995) who designed and tested such an auger for containers of rectangular cross-section, and determined flow to be uniform for practical purposes. The analysis follows the same …