Engineering Commons^™

Increased Susceptibility Of Arterial Tissue To Wire Perforation With The Application Of High Frequency Mechanical Vibrations, Mark Wylie, Garrett Mcguinness, Graham Gavin

Articles

High frequency mechanical vibrations (20–50 kHz), delivered via small diameter flexible wire waveguides represent a minimally invasive technology for the treatment of chronic total occlusions (CTOs) and in other tissue ablation applications. Tissue disruption is reported to be caused by repetitive mechanical contact and cavitation. This work focuses on the effects of vibrating wire waveguides in contact with arterial tissue. An apparatus with clinically relevant parameters was used, characterized as operating at 22.5 kHz and delivering amplitudes of vibration of 17.8 - 34.3 µm (acoustic intensity, I_SATA: 1.03 - 3.83 W/cm²) via 1.0 mm diameter waveguides. …

High Power, Low Frequency Ultrasound: Meniscal Tissue Interaction And Ablation Characteristics, Brendan O'Daly, Edmund Morris, Graham Gavin, Conor Keane, John O Byrne, Garrett Mcguinness

Articles

Abstract—This study evaluates high power low frequency ultrasound transmitted via a flat vibrating probe tip as an alternative technology for meniscal debridement in the bovine knee. An experimental force controlled testing rig was constructed using a 20 kHz ultrasonic probe suspended vertically from a load cell. Effect of variation in amplitude of distal tip displacement (242–494 mm peak-peak) settings and force (2.5–4.5 N) on tissue removal rate (TRR) and penetration rate (PR) for 52 bovine meniscus samples was analyzed. Temperature elevation in residual meniscus was measured by embedded thermocouples and histologic analysis. As amplitude or force increases, there is a …

Perforation Of Arterial Tissue Using Kilohertz Frequency Ultrasound Delivered Via Wire Waveguides, Mark Wylie, Garrett Mcguinness, Graham Gavin

Conference Papers

An emerging technology proposes the use of low frequency-high power ultrasound transmitted via wire waveguides for the disruption and ablation of atherosclerotic lesions, more specifically advanced fibrous or calcified plaques such as chronic total occlusions (CTO). This energy delivery selectively ablates rigid diseased tissue by means of direct mechanical contact, cavitation and other forces generated by the intense dynamic pressure fields generated.

The first clinical device using this energy delivery was granted FDA approval in 2007 [1] for the ablation of CTOs and most research to date has focused on ablation and disruption of hard, fibrous or calcified tissues [2]. …

A Linear Finite Element Acoustic Fluid-Structure Model Of Ultrasonic Angioplasty In Vivo, Mark Wylie, Garrett Mcguinness, Graham Gavin

Articles

The delivery of high-power ultrasonic energy via small diameter wire waveguides represents a new alternative therapy for the treatment of chronic totally occluded arteries (CTOs). This type of energy manifests itself as a mechanical vibration at the distal-tip of the waveguide with amplitudes of vibration up to 60 µm and at frequencies of 20- 50 kHz. Disruption of diseased tissue is reported to be a result of direct mechanical ablation, cavitation, pressure components and acoustic streaming and that ablation was only evident above the cavitation threshold. This work presents a linear finite element acoustic fluid-structure model of an ultrasonic angioplasty …

High-Power Low-Frequency Ultrasound: A Review Of Tissue Dissection And Ablation In Medicine And Surgery, Brendan O'Daly, Edmund Morris, Graham Gavin, John O'Byrne, Garrett Mcguinness

Articles

High-power low-frequency ultrasound in the range 20–60 kHz has wide ranging clinical applications in surgical and medical instruments for biological tissue cutting, ablation or fragmentation, and removal. Despite widespread clinical application and common device operating characteristics, there is an incomplete understanding of the mechanism of tissue failure, removal and damage. The relative contribution of cavitation, direct mechanical impact and thermal effects to each process for specific tissue types remains unclear. Different and distinct mechanisms and rates of tissue removal are observed for interaction with soft and hard tissue types. Device operating parameters known to affect the interaction include frequency, peak–peak …

Experimental And Numerical Investigation Of Wire Waveguides For Therapeutic Ultrasound Angioplasty, Declan Noone (Thesis)

Other resources

Therapeutic ultrasound angioplasty is an emerging minimally invasive cardiovascular procedure for disrupting atherosclerotic lesions using small diameter wire waveguides. The lesions are damaged through a combination of direct ablation, pressure waves, cavitation and acoustic streaming caused by distal-tip displacements at ultrasonic frequencies. Numerical and experimental methods are used to investigate the outputs of the wire waveguides during ultrasonic activation. A commercially available generator and acoustic horn are used in combination with Nickel-Titanium (NiTi) wire waveguides in this study. A laser sensor is used to measure the frequency and amplitude output of the distal tip of the wire waveguide, and this …

A Coupled Fluid-Structure Model Of A Therapeutic Ultrasound Angioplasty Wire Waveguide, Graham Gavin, Finbar Dolan, M.S. Hashmi, Garrett Mcguinness

Articles

Ultrasonic longitudinal displacements, delivered to the distal tips of small diameter wire waveguides, have been shown to be capable of disrupting complicated atherosclerotic plaques during vascular interventions. These ultrasonic displacements can disrupt plaques by direct contact ablation but also by pressure waves, associated cavitation and acoustic streaming developed in the surrounding blood and tissue cavities. The pressure waves developed within the arterial lumen appear to play a major role but are complex to predict as they are determined by the distal tip output of the wire waveguide (both displacement and frequency), the geometric features of the waveguide tip and the …

Performance Characteristics Of A Therapeutic Ultrasound Wire Waveguide, Graham Gavin, Garrett Mcguinness, Finbar Dolan, M.S. Hashmi

Articles

Therapeutic ultrasound angioplasty has been investigated, clinically, by a number of researchers and represents a potentially promising therapy for the treatment of atherosclerotic lesions. To date, there has been no detailed analysis of the effect of mechanical design parameters, such as wire geometry or damping characteristics, on wire waveguide performance. An apparatus capable of delivering therapeutic ultrasound down small diameter nickel–titanium (NiTi) wire waveguides is described. The output peak-to-peak (p–p) displacements at the distal tip of a 1.0mm diameter waveguide were measured experimentally, by means of an optical microscope and image analysis software. The output was measured for a range …

An Acoustic Fluid-Structure Simulation Of A Theraputic Ultrasound Wire Waveguide Apparatus, Graham Gavin, M.S. Hashmi, Finbar Dolan, Garrett Mcguinness

Conference Papers

The use of high-power low-frequency ultrasound transmitted down small diameter wire waveguides is an emerging technology that may have potential in the treatment of complicated atherosclerotic plaques in cardiovascular surgery. This form of energy delivery results in vibrating the distal-tip of the wire waveguide disrupting material by means of direct contact ablation and also cavitation, pressure waves and acoustic streaming in the surrounding fluid. This work describes a numerical acoustic fluid-structure model of the ultrasound wire waveguide and blood surrounding the distal tip. The structural analysis of the model predicts the natural frequencies of the waveguide and shows the extent …