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Full-Text Articles in Engineering
Release Of Hydrophobic Molecules From Polymer Micelles Into Cell Membranes Revealed By Forster Resonance Energy Transfer Imaging, Hongtao Chen, Sungwon Kim, Shuyi Wang, Kinam Park, Ji-Xin Cheng
Release Of Hydrophobic Molecules From Polymer Micelles Into Cell Membranes Revealed By Forster Resonance Energy Transfer Imaging, Hongtao Chen, Sungwon Kim, Shuyi Wang, Kinam Park, Ji-Xin Cheng
Other Nanotechnology Publications
it is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing fluorescently labeled copolymers and hydrophobic fluorescent probes entrapped in the polymeric micelle core showed that cellular uptake of hydrophobic probes was much faster than that of labeled copolymers. This result implies that the hydrophobic probes in the core are released from micelles in the extracellular space. Forster resonance energy transfer (FRET) imaging and spectroscopy were used to monitor this process …
A New Paradigm For Human Resuscitation Research Using Intelligent Devices, Charles F. Babbs, Andre E. Kemeny, Weilun Quan, Gary Freeman
A New Paradigm For Human Resuscitation Research Using Intelligent Devices, Charles F. Babbs, Andre E. Kemeny, Weilun Quan, Gary Freeman
Weldon School of Biomedical Engineering Faculty Publications
Objectives: To develop new methods for studying correlations between the performance and outcome of resuscitation efforts in real-world clinical settings using data recorded by automatic devices such as automatic external defibrillators (AEDs), and to explore effects of shock timing and chest compression depth in the field. Methods: In 695 records of AED use in the pre-hospital setting, continuous compression data were recorded using AEDs capable of measuring sternal motion during compressions, together with timing of delivered shocks and the electrocardiogram. In patients who received at least one shock, putative return of spontaneous circulation (P-ROSC) was defined as a regular, narrow …