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Optimized Xanthene-Based Probes For Pancreatic Cancer Imaging, Ian Ruramai Munhenzva
Optimized Xanthene-Based Probes For Pancreatic Cancer Imaging, Ian Ruramai Munhenzva
Dissertations and Theses
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the deadliest human malignancies with an extremely poor 5-year survival rate of below 5%. Surgical resection is the most effective treatment of choice because chemotherapy and radiation therapy do not improve life expectancy. Residual tumor after PDAC surgery is common due to a lack of PDAC targeted intraoperative contrast agents to confirm clear margins.
Fluorescence imaging has the potential to improve surgery outcome and PDAC patients' survival rate via the use of highly PDAC-specific molecular probes to facilitate tumor identification. This thesis describes the application of a focused library of benzoxanthene fluorophores for …