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Assessing The Prediction Potential Of An In Silico Computer Model Of Intracranial Pressure Dynamics, Wayne Wakeland, Rachel Agbeko, Kevin Vinecore, Mark Peters, Brahm Goldstein
Assessing The Prediction Potential Of An In Silico Computer Model Of Intracranial Pressure Dynamics, Wayne Wakeland, Rachel Agbeko, Kevin Vinecore, Mark Peters, Brahm Goldstein
Systems Science Faculty Publications and Presentations
Objective: Traumatic brain injury (TBI) frequently results in poor outcome, suggesting that new approaches are needed. We hypothesized that a patient-specific in silico computer model of intracranial pressure (ICP) dynamics may predict the ICP response to therapy.
Design: In silico model analysis of prospectively collected data.
Setting: Twenty-three and 16-bed pediatric intensive care units in two tertiary care academic hospitals.
Patients: Nine subjects with severe TBI undergoing ICP monitoring (7 M/2 F, age range 3-17 years).
Interventions: Random changes in head-of-bed (HOB) (0[degrees], 10[degrees], 20[degrees], 30[degrees], 40[degrees]) elevation and respiratory rate (to achieve a [DELTA]ETco2 = +/-3-4 mm Hg) were …