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Assessing The Prediction Potential Of An In Silico Computer Model Of Intracranial Pressure Dynamics, Wayne Wakeland, Rachel Agbeko, Kevin Vinecore, Mark Peters, Brahm Goldstein
Assessing The Prediction Potential Of An In Silico Computer Model Of Intracranial Pressure Dynamics, Wayne Wakeland, Rachel Agbeko, Kevin Vinecore, Mark Peters, Brahm Goldstein
Systems Science Faculty Publications and Presentations
Objective: Traumatic brain injury (TBI) frequently results in poor outcome, suggesting that new approaches are needed. We hypothesized that a patient-specific in silico computer model of intracranial pressure (ICP) dynamics may predict the ICP response to therapy.
Design: In silico model analysis of prospectively collected data.
Setting: Twenty-three and 16-bed pediatric intensive care units in two tertiary care academic hospitals.
Patients: Nine subjects with severe TBI undergoing ICP monitoring (7 M/2 F, age range 3-17 years).
Interventions: Random changes in head-of-bed (HOB) (0[degrees], 10[degrees], 20[degrees], 30[degrees], 40[degrees]) elevation and respiratory rate (to achieve a [DELTA]ETco2 = +/-3-4 mm Hg) were …
Reproducing Published Results From In Silico Computer Models Of The Acute Inflammatory Response To Severe Sepsis, Wayne W. Wakeland, Joe Fusion, Brahm Goldstein
Reproducing Published Results From In Silico Computer Models Of The Acute Inflammatory Response To Severe Sepsis, Wayne W. Wakeland, Joe Fusion, Brahm Goldstein
Systems Science Faculty Publications and Presentations
Recent studies describe computer simulation models of the acute or systemic inflammatory response (AIR or SIR) to severe sepsis, a condition that can lead to multiple organ failure and death. One study used an agent-based model, while the other used differential equations (DEs) to simulate a randomized clinical trial. Both studies obtained results similar to the actual results from a successful clinical drug trial of severe sepsis, suggesting that in silico (simulated) randomized clinical trials may be used to design more effective in vivo clinical trials.