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Collagen V Promotes Fibroblast Contractility, And Adhesion Formation, And Stability, Shaina P. Royer-Weeden
Collagen V Promotes Fibroblast Contractility, And Adhesion Formation, And Stability, Shaina P. Royer-Weeden
Dissertations, Master's Theses and Master's Reports
Ehlers-Danlos syndrome, classical type, (cEDS) is a hereditary connective tissue disorder causing excessive elasticity and fragility of the connective tissue and problems with wound healing. Most cases of cEDS are caused by haploinsufficiency for collagen V. Collagen V regulates collagen fibril diameter. In cEDS fibroblast migration is impaired and integrin expression is altered.
The effects of collagen V on collagen gel ultrastructure and how it alters its mechanical properties were measured using scanning electron microscopy (SEM) and rheology respectively. Fibroblast contractility and adhesion dynamics were investigated to better understand the role of fibroblast disfunction in wound healing in cEDS. To …