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Full-Text Articles in Engineering

A Novel Method For Characterization Of Peripheral Nerve Fiber Size Distributions By Group Delay, Robert B. Szlavik Dec 2008

A Novel Method For Characterization Of Peripheral Nerve Fiber Size Distributions By Group Delay, Robert B. Szlavik

Biomedical Engineering

The ability to determine the characteristics of peripheral nerve fiber size distributions would provide additional information to clinicians for the diagnosis of specific pathologies of the peripheral nervous system. Investigation of these conditions, using electrodiagnostic techniques, is advantageous in the sense that such techniques tend to be minimally invasive yet provide valuable diagnostic information. One of the principal electrodiagnostic tools available to the clinician is the nerve conduction velocity test. While the peripheral nerve conduction velocity test can provide useful information to the clinician regarding the viability of the nerve under study, it is a single-parameter test that yields no …


Design And Optimization Of A Blood Vessel Mimic Bioreactor System For The Evaluation Of Intravascular Devices In Simple And Complex Vessel Geometries, Sara M. Leifer Nov 2008

Design And Optimization Of A Blood Vessel Mimic Bioreactor System For The Evaluation Of Intravascular Devices In Simple And Complex Vessel Geometries, Sara M. Leifer

Master's Theses

Coronary artery disease affects millions of people and the ability to detect and treat the disease is advancing at a rapid rate. As a result, the development of intravascular technologies is the focus of many medical device manufacturers. Specifically, coronary stent implantation is being performed in an increasing number of patients and a number of new stent designs have been introduced to the market, resulting in the need for improved preclinical testing methods. An in vitro tissue engineered “blood vessel mimic” (BVM) system has previously been established and its feasibility for the initial testing of newly emerging intravascular technology has …


Teaching Physiology To Biomedical Engineers Using Team-Based Learning And Inquiry Research, Trevor R. Cardinal Oct 2008

Teaching Physiology To Biomedical Engineers Using Team-Based Learning And Inquiry Research, Trevor R. Cardinal

Biomedical Engineering

Presentation given at conference.


Volume Effects On Yield Strength Of Equine Cortical Bone, R. F. Bigley, J. C. Gibeling, S. M. Stover, S. J. Hazelwood, D. P. Fyhrie, R. B. Martin Oct 2008

Volume Effects On Yield Strength Of Equine Cortical Bone, R. F. Bigley, J. C. Gibeling, S. M. Stover, S. J. Hazelwood, D. P. Fyhrie, R. B. Martin

Biomedical Engineering

Volume effects are a fundamental determinant of structural failure. A material exhibits a volume effect if its failure properties are dependent on the specimen volume. Many brittle ceramics exhibit volume effects due to loading a structure in the presence of “critical” flaws. The number of flaws, their locations, and the effect of stress field within the stressed volume play a role in determining the structure’s failure properties. Since real materials are imperfect, structures composed of large volumes of material have higher probabilities of containing a flaw than do small volumes. Consequently, large material volumes tend to fail at lower stresses …


Fatigue Testing Of Three Peristernal Median Sternotomy Closure Techniques, Cameron Wangsgard, David J. Cohen, Lanny V. Griffin Sep 2008

Fatigue Testing Of Three Peristernal Median Sternotomy Closure Techniques, Cameron Wangsgard, David J. Cohen, Lanny V. Griffin

Biomedical Engineering

Failure of a sternotomy closure because of closure system fatigue is a complication that may result in dehiscence and put the individual at risk for serious complications. The purpose of this study was to assess the fatigue performance of three peristernal median sternotomy closure techniques (figure-of-eight stainless-steel wires, figure-of-eight stainless-steel cables, or Pectofix Dynamic Sternal Fixation [DSF] stainless-steel plates) in order to quantify the potential risk of fatigue failure of these devices when subject to cyclic loads in physiologically relevant loading directions.


A Novel Method For Characterization Of Peripheral Nerve Fiber Size Distributions By Group Delay Measurements And Simulated Annealing Optimization, Robert B. Szlavik, Galen E. Turner, Iii Aug 2008

A Novel Method For Characterization Of Peripheral Nerve Fiber Size Distributions By Group Delay Measurements And Simulated Annealing Optimization, Robert B. Szlavik, Galen E. Turner, Iii

Biomedical Engineering

The ability to determine the characteristics of peripheral nerve fiber size distributions would provide additional information to clinicians for the diagnosis of specific pathologies of the peripheral nervous system. Investigation of these conditions, using electro-diagnostic techniques, is advantageous in the sense that such techniques tend to be minimally invasive yet provide valuable diagnostic information. One of the principal electro-diagnostic tools available to the clinician is the nerve conduction velocity test. While the peripheral nerve conduction velocity test can provide useful information to the clinician regarding the viability of the nerve under study, it is a single parameter test that yields …


Action At Distance: A Ms Degree Offered Through Distance Learning As A Vector To Student Enrichment And Industrial Interaction, Lanny Griffin, Daniel Walsh, Robert Crockett, Robert B. Szlavik Jun 2008

Action At Distance: A Ms Degree Offered Through Distance Learning As A Vector To Student Enrichment And Industrial Interaction, Lanny Griffin, Daniel Walsh, Robert Crockett, Robert B. Szlavik

Biomedical Engineering

This paper describes the development and implementation of a flourishing MS program offered through distance learning (DL). The program serves the mission of the university – polytechnic education. It provides an intense life-long-learning opportunity for some of the 300,000 degreed engineers working in California industry who can benefit from graduate education. The DL Masters Degree Program in Engineering with a Biomedical Specialization was designed and developed with verisimilitude to the on-campus program in mind. The distance students attend the same classes as students on campus. The DL program has the same learning objectives and student outcomes as those expected for …


Nicotinic Acetylcholine Receptor Kinetics Of The Neuromuscular Junction Simulated Using Spice: An Illustration Of Physiological Process Simulation With Conventional Circuit Simulation Software, Robert B. Szlavik Jun 2008

Nicotinic Acetylcholine Receptor Kinetics Of The Neuromuscular Junction Simulated Using Spice: An Illustration Of Physiological Process Simulation With Conventional Circuit Simulation Software, Robert B. Szlavik

Biomedical Engineering

With the advent of modern day computational power, there is a great deal of interest in the simulation and modeling of complex biological systems. A significant effort is being made to develop generalized software packages for the simulation of cellular processes, metabolic pathways and complex biochemical reaction systems. The advantages to being able to implement and simulate complex biological systems in a virtual environment are several. Simulations of this type, if sufficiently detailed, provide experimental physiologists with the ability to visualize the dynamics of a given biological system of interest. The validity of hypotheses related to the system under study …


An Automatic Alogorithm For Detecting Stent Endothelialization From Volumetric Optical Coherence Tomography Datasets, Garret T. Bonnema, Kristen O'Halloran Cardinal, Stuart K. Williams, Jennifer K. Barton Jun 2008

An Automatic Alogorithm For Detecting Stent Endothelialization From Volumetric Optical Coherence Tomography Datasets, Garret T. Bonnema, Kristen O'Halloran Cardinal, Stuart K. Williams, Jennifer K. Barton

Biomedical Engineering

Recent research has suggested that endothelialization of vascular stents is crucial to reducing the risk of late stent thrombosis. With a resolution of approximately 10 μm, optical coherence tomography (OCT) may be an appropriate imaging modality for visualizing the vascular response to a stent and measuring the percentage of struts covered with an anti-thrombogenic cellular lining. We developed an image analysis program to locate covered and uncovered stent struts in OCT images of tissue-engineered blood vessels. The struts were found by exploiting the highly reflective and shadowing characteristics of the metallic stent material. Coverage was evaluated by comparing the luminal …


A Case-Study Based Course On "Device Evaluation And Fda Approval", Kristen O'Halloran Cardinal Jun 2008

A Case-Study Based Course On "Device Evaluation And Fda Approval", Kristen O'Halloran Cardinal

Biomedical Engineering

Preclinical evaluation of new devices and therapies is an integral part of research and development in the medical device industry, and the regulatory process for FDA approval is a major driving force behind much that goes on in a company setting. A large number of graduating biomedical engineers enter this medical device industry or a related environment upon graduation from our institution. Although these engineers are equipped to address many of the technical challenges that will arise, there is currently limited formal training in or exposure to the regulatory process that is required to bring new devices to market. Knowledge …


Development Of A Cell Depositing System Using Inkjet Technology, Jason Robert Ozaeta Jun 2008

Development Of A Cell Depositing System Using Inkjet Technology, Jason Robert Ozaeta

Master's Theses

In the past decade, advances in tissue engineering have allowed researchers to fabricate simple tissues. However, the process of creating these native tissues is a time consuming and inefficient process. A scaffold must first be fabricated then exposed to a sea of cells in the hopes of seeding. Furthermore, even though cells may have attached, more time must be spent in order to allow the cells to migrate to their ideal locations. To deal with this problem, researchers have investigated whether rapid prototyping principals could be adapted to facilitate the cell seeding process by placing cells in their respective locations …