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Full-Text Articles in Engineering
Methodology For Formalin Fixed Paraffin Embedded Cardiac Tissue Analysis, Leah G. Gutzwiller, Colleen Crouch
Methodology For Formalin Fixed Paraffin Embedded Cardiac Tissue Analysis, Leah G. Gutzwiller, Colleen Crouch
Haslam Scholars Projects
No abstract provided.
Friend Or Foe? The Role Of Transforming Growth Factor-Β (Tgfβ) Signaling In Calcineurin Inhibitor-Induced Renal Damage, Adaku Ume
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With its incorporation into clinical practice in the early 1980s, the class of pharmacological agents known as calcineurin inhibitors (CNIs) quickly became the cornerstone of immunosuppressive therapy post-organ transplantation. However, its use is limited by irreversible kidney damage in the form of renal fibrosis. The molecular mechanism by which CNIs induce renal fibrosis remains to be better understood, and to date, there are no specific therapeutic strategies to mitigate this damage. This dilemma presents a critical need to explain mechanisms by which CNIs cause renal damage. Kidneys of patients on chronic CNI therapy show increased expression of the proinflammatory cytokine …
Identifying A Novel Ferrocene Derivative As A K-Ras Inhibitor, Kristen Marie Rehl
Identifying A Novel Ferrocene Derivative As A K-Ras Inhibitor, Kristen Marie Rehl
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Ras proteins are small GTPases that regulate cell proliferation, differentiation and survival at the plasma membrane (PM). There are three Ras isoforms ubiquitously expressed in mammalian cells: H-, N- and K-Ras. Constitutively active Ras mutations are found in ~19% of all human cancers, with ~75% of those being in K-Ras. There are K-Ras inhibitors in clinic but they only target the oncogenic K-RasG12C mutant, which only makes up a small sub-set of K-Ras-driven cancers. Thus, there still exists a need for a pan anti-K-Ras drug. Ferrocene derivatives are a class of compounds that have been shown to inhibit the growth …
Brain Morphometry From Neuroimaging As A Biomarker For Alzheimer's Disease, Nonyelum Benedicta Aniebo
Brain Morphometry From Neuroimaging As A Biomarker For Alzheimer's Disease, Nonyelum Benedicta Aniebo
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Alzheimer’s disease (AD) is the seventh leading cause of death globally with an estimated 6.5 million Americans aged 65 and above living with Alzheimer’s dementia in 2022 and at a projected national cost of $321 billion. AD is characterized by a progressive and irreversible neurodegenerative dysfunction with clinical symptoms such as deterioration in cognition and memory loss. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a multi-site, public-private global research initiative that supports both investigation and development of treatments that slow or terminate AD progression. The study included 60 participants, comprising 30 AD and 30 control cohorts respectively. All participants were …
Frostflex, Isaac Edmondson, Caleb Edmondson, Joey Esker, Nadine Salem
Frostflex, Isaac Edmondson, Caleb Edmondson, Joey Esker, Nadine Salem
Williams Honors College, Honors Research Projects
Research has shown that the majority of heat lost during physical exercise leaves the body through the hands, feet, and the face. Our design project seeks to develop cooling glove technology to increase the rate at which heat leaves the body during recovery from physical exertion. The goal of this project was to investigate different ways in which heat absorption through various mediums can be manipulated and scaled into an adaptable, flexible design in which athletes of all levels, from recreational to professional, can improve their physical performance with the use of our gloves. Deliverables include a functional prototype, product …