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Articles 1 - 30 of 102
Full-Text Articles in Engineering
Spin Coating Multilayer Polymer Films To Improve The Consistency And Longevity Of Interval Drug Release, Katherine Nevils
Spin Coating Multilayer Polymer Films To Improve The Consistency And Longevity Of Interval Drug Release, Katherine Nevils
Honors Theses
Treatment-resistant depression (TRD) is a clinical diagnosis for patients suffering from major depressive disorder (MDD). An inadequate response to the dosage or duration of antidepressant medication can lead to the diagnosis of TRD. This diagnosis is common in up to 50% of patients with MDD following treatment. Microdosing of classical psychedelics such as lysergic acid diethylamide (LSD) has been shown to have positive cognitive and therapeutic effects on patients with TRD. However, issues of patient compliance to the complex regimen and abuse/diversion of the schedule I controlled substances remain unresolved. The goal of this project is to create an implantable, …
Creating A Collapsible Sling Lift Capable Of Transporting Patients Between Various Locations, Cameron Delaney Hillman, Macey Jewell Ross, Lydia Noel Miller
Creating A Collapsible Sling Lift Capable Of Transporting Patients Between Various Locations, Cameron Delaney Hillman, Macey Jewell Ross, Lydia Noel Miller
Honors Theses
As Senior Biomedical Engineering students at the University of Mississippi, we, Lainey Hillman, Lydia Miller, and Macey Ross, are required to complete a final senior capstone for our department. This project aims to provide a solution to a current unmet clinical need in the healthcare industry, thus our team sought to improve the lack of transportability of sling lifts. The current sling lifts on the market display numerous issues: heavy, bulky, use confined to certain areas, and use specific for only one type of transportation. To combat these problems, we designed a sling lift that was lightweight, collapsible, safe, and …
Creating A Collapsible Sling Lift Capable Of Transporting Patients Between Various Locations, Macey Jewell Ross, Cameron Delaney Hillman, Lydia Noel Miller
Creating A Collapsible Sling Lift Capable Of Transporting Patients Between Various Locations, Macey Jewell Ross, Cameron Delaney Hillman, Lydia Noel Miller
Honors Theses
As Senior Biomedical Engineering students at the University of Mississippi, we, Lainey Hillman, Lydia Miller, and Macey Ross, are required to complete a final senior capstone for our department. This project aims to provide a solution to a current unmet clinical need in the healthcare industry, thus our team sought to improve the lack of transportability of sling lifts. The current sling lifts on the market display numerous issues: heavy, bulky, use confined to certain areas, and use specific for only one type of transportation. To combat these problems, we designed a sling lift that was lightweight, collapsible, safe, and …
Variable Design Stent To Prevent Stent Failure In Areas Of High Mobility In Peripheral Artery Disease Patients, Emmie Stevens, Brennan Toepfer, Lexi Graves
Variable Design Stent To Prevent Stent Failure In Areas Of High Mobility In Peripheral Artery Disease Patients, Emmie Stevens, Brennan Toepfer, Lexi Graves
Honors Theses
As senior biomedical engineering students at the University of Mississippi, we were tasked with a senior project to find an unmet clinical need in the healthcare industry and design a way to solve it. Our team, consisting of Hannah Dunn, Lexi Graves, Emmie Stevens, and Brennan Toepfer, decided to improve upon current stents to create a stent more suited to treating Peripheral Artery Disease (PAD), especially in high-impact areas, such as the back of the knee joint. Stents placed in the back of the knee have a high level of stent failure due to the high movement of the knee …
Minimizing Patient Migration: Enhancing Safety And Comfort For Patients And Caregivers In Bedridden Care, Danielle Pasquini
Minimizing Patient Migration: Enhancing Safety And Comfort For Patients And Caregivers In Bedridden Care, Danielle Pasquini
Honors Theses
Biomedical engineering seniors at the University of Mississippi embark on a senior project aimed at addressing an unmet clinical need. Our team, consisting of Kelsie Hand, Christian Miller, and Danielle Pasquini, identified a prevalent issue of bedridden patients slipping down in bed, leading to increased repositioning by caregivers. This not only impacts patient comfort but also poses risks of complications such as pressure ulcers and caregiver injuries. In our efforts to tackle the issue of patient slippage among bedridden individuals, our team introduced a novel solution comprising a non-slip vest for patients and a corresponding non-slip sheet attachment. This integrated …
Suppressing Reactive Oxygen Species Via Application Of Antioxidant Supramolecular Polymers, Zacchaeus Wallace
Suppressing Reactive Oxygen Species Via Application Of Antioxidant Supramolecular Polymers, Zacchaeus Wallace
Honors Theses
Cardiovascular diseases along with various other disease conditions are characterized by an upregulation in reactive oxygen species (ROS), which can overwhelm homeostatic processes in the body, resulting in cellular apoptosis and severe oxidative damage. The lack of clinically approved treatments to regulate or alleviate this elevated ROS presence underscores the need for novel therapeutic strategies. While antioxidants promote cell rescue through ROS scavenging, their clinical translation is impeded by insufficient bioavailable concentrations at the source of injury. The opportunity to apply antioxidant supramolecular polymers of peptide amphiphiles (PAs) is an exciting prospect of research to combat corresponding issues. For this …
Biophysical Study Of The Von Willebrand Factor Via Optical Tweezers—Investigating The Collagen Binding Force Profile To Distinguish Types Of Von Willebrand Disease, Leigh Hardin
Honors Theses
von Willebrand disease (vWD) is a genetic disorder due to quantitative or qualitative abnormalities of the von Willebrand factor (vWF). There are three main types of vWD in addition to acquired von Willebrand syndrome. Type 1 is due to a deficiency of vWF, while Type 3 is due to a complete absence of vWF. Type 2 is due to malformed factors and broken into four subtypes: 2A, 2B, 2M, and 2N. Each subtype corresponds to different abnormalities of the protein that affect its binding to other proteins such as collagen, Factor VIII, platelets, etc. Therefore, determining a patient’s type and …
Exploring The Use Of Virtual Reality In Designing And Prototyping Medical Devices, Evan Marsh
Exploring The Use Of Virtual Reality In Designing And Prototyping Medical Devices, Evan Marsh
Honors Theses
A degree in engineering is highly sought after in the United States. Despite the grueling coursework and sacrifices involved in earning an engineering degree, the rewards after college are numerous. However, the engineering field is vast, and the degree obtained is not always the profession followed in industry. A lot of what we learn in the college of engineering is very broad and surface-level. It is worth noting that only about 10% of what engineering students learn in school is applicable in the workplace, but they wish they had learned a lot more about that 10%.
The Biological Activity Of Dual-Responsive Glycopolymers For Intracellular Codelivery Of Antigen And Lipophilic Adjuvant, Micaela Shields
The Biological Activity Of Dual-Responsive Glycopolymers For Intracellular Codelivery Of Antigen And Lipophilic Adjuvant, Micaela Shields
Honors Theses
Subunit vaccines present themselves as an attractive alternative to traditional approaches to vaccines, which utilizes whole organisms to trigger an immune response. While these traditional approaches have proven themselves reliable within the history of vaccinations, they generally deliver subpar robust cellular-mediated immunity and pose many safety risks. Composed of proteins and /or peptides, subunit vaccines are safer and more precise alternatives to traditional approaches. However, the pharmacokinetic properties of the macromolecules that make up these vaccines hinder the subunit vaccine’s level of immunogenicity [d1] Examples of this hindrance include but are not limited to aggregation at the injection site and …
The Antler: The Design And Development Of An Independent Shower Support Stand For Those Living With Lower Extremity Limb Loss, Kylie Wright
The Antler: The Design And Development Of An Independent Shower Support Stand For Those Living With Lower Extremity Limb Loss, Kylie Wright
Honors Theses
While we do not often think about it, taking a shower is a privilege. Standing in the hot water, cleaning off after a long day outdoors, and taking a moment to simply relax is an experience that most people in the U.S. have participated in. However, about 1.4 million Americans do not have this luxury3. Lower extremity amputees have long been advised to shower while seated for their safety. This population is unable to experience the simple independence that accompanies standing in the shower. Despite the growing rate of amputations each year, no products are currently available on the market …
Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Sydney Ruth Rester, Shelby Lynn Berry
Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Sydney Ruth Rester, Shelby Lynn Berry
Honors Theses
Seniors at the University of Mississippi studying biomedical engineering complete a senior project that seeks to solve a problem in healthcare. Our team, composed of Sydney Rester, Shelby Berry, Andrew Ulmer, and Alex Bromley, sought to improve care associated with nasogastric feeding tubes. We identified two major problems: clogging and tube dislodgement. To address the problem of dislodgement, the team crafted a new feeding tube design with a balloon attachment. The attachment prevents a patient from pulling the feeding tube out and keeps the tube from dislodging due to normal patient movement. We further determined that our tube should be …
Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Shelby Lynn Berry, Sydney Ruth Rester
Redesigning Nasogastric Feeding Tubes To Prevent Dislodgement, Shelby Lynn Berry, Sydney Ruth Rester
Honors Theses
Seniors at the University of Mississippi studying biomedical engineering complete a senior project that seeks to solve a problem in healthcare. Our team, composed of Sydney Rester, Shelby Berry, Andrew Ulmer, and Alex Bromley, sought to improve care associated with nasogastric feeding tubes. We identified two major problems: clogging and tube dislodgement. To address the problem of dislodgement, the team crafted a new feeding tube design with a balloon attachment. The attachment prevents a patient from pulling the feeding tube out and keeps the tube from dislodging due to normal patient movement. We further determined that our tube should be …
Investigating Myosin Ensemble Force Generation Using Optical Tweezers, Janie Watts
Investigating Myosin Ensemble Force Generation Using Optical Tweezers, Janie Watts
Honors Theses
Myosin is a motor protein that facilitates muscle contraction and movement by stepping along actin filaments using energy from ATP hydrolysis. If myosin or other motors are disrupted throughout the body, it can have many harmful effects. Hypertrophic cardiomyopathy is a disease caused by gene mutations that affect myosin heavy chains in the heart. The tissue of the heart becomes abnormally thick, which can make it more difficult to pump blood or block blood flow out of the heart. Our goal is to discern the mechanistic difference function of a healthy and diseased heart. To accomplish this, we construct model …
A Device For Measuring Acoustic Output Intensity Of Transcranial Doppler Ultrasound Transducers For Comparison With Fda Regulations, Sarah Altman, Gregory Bashford, Benjamin Hage
A Device For Measuring Acoustic Output Intensity Of Transcranial Doppler Ultrasound Transducers For Comparison With Fda Regulations, Sarah Altman, Gregory Bashford, Benjamin Hage
Honors Theses
Transcranial Doppler Ultrasonography (TCD) is a non-invasive methodology which can evaluate cerebral blood flow velocity in real time. Single-element focused circular transducers placed on the scalp produce ultrasound waves capable of penetrating the skull with minimal aberration, enabling measurement of the Doppler shift. As such, TCD can measure blood flow velocity in the internal carotid and vertebral arteries, as well as the arteries of the Circle of Willis: the Anterior Cerebral (ACA), Posterior Cerebral (PCA), and Middle Cerebral Arteries (MCA). Intracranial aneurysm and ischemic stroke are serious conditions in which ballooning or occlusion of cerebral vessels cause insufficient perfusion, leading …
On The Pursuit Of Developer Happiness: Webcam-Based Eye Tracking And Affect Recognition In The Ide, Tamsin Rogers
On The Pursuit Of Developer Happiness: Webcam-Based Eye Tracking And Affect Recognition In The Ide, Tamsin Rogers
Honors Theses
Recent research highlights the viability of webcam-based eye tracking as a low-cost alternative to dedicated remote eye trackers. Simultaneously, research shows the importance of understanding emotions of software developers, where it was found that emotions have significant effects on productivity, code quality, and team dynamics. In this paper, we present our work towards an integrated eye-tracking and affect recognition tool for use during software development. This combined approach could enhance our understanding of software development by combining information about the code developers are looking at, along with the emotions they experience. The presented tool utilizes an unmodified webcam to capture …
Evaluating The Viscoelastic Properties Of Alligator Skin Gelatin, Alligel, Compared To Mammalian And Fish Gelatins, Sarah E. Jimenez
Evaluating The Viscoelastic Properties Of Alligator Skin Gelatin, Alligel, Compared To Mammalian And Fish Gelatins, Sarah E. Jimenez
Honors Theses
No abstract provided.
Simpliscope: A Novel Device For In-Office Laryngeal Biopsies, Margaret Schuermann, Aris Rassias, Noah Barney, Alexandra Lipsky
Simpliscope: A Novel Device For In-Office Laryngeal Biopsies, Margaret Schuermann, Aris Rassias, Noah Barney, Alexandra Lipsky
Honors Theses
In order to screen for laryngeal cancer, a biopsy is performed to take a tissue sample from that area of interest. Due to the risk involved these procedures take place in the operating room where a larger sample can be obtained, but delays in scheduling operating room procedures put patients at a greater risk as their diagnosis can be delayed. We want to create a device that is able to move these delayed operating room procedures in-of ice where the physician can treat the patient quickly and safely. Our goal is to increase the accuracy of in-office laryngeal biopsies while …
The Synthesis And Characterization Of Ionic Liquids Using Nitrogen-Based Cations For Transdermal Delivery, Jo Galloway
The Synthesis And Characterization Of Ionic Liquids Using Nitrogen-Based Cations For Transdermal Delivery, Jo Galloway
Honors Theses
The purpose of this research was to explore the synthesis mechanisms of water-soluble ionic liquids with nitrogen-containing cationic bases for future use in transdermal drug delivery and forensic science applications. Ionic liquids are salts with an organic cation and either an organic or inorganic anion. They have asymmetric structures, which means that the molecules don’t pack together as neatly as other salts do, therefore, they don’t crystallize as easily, and their melting points are lower. Ionic liquids have melting points below 100°C, and many are liquid at room temperature. Mechanistic studies reveal that the potency of ILs in enhancing transdermal …
Th1, Th2, And Th17 Inflammatory Pathways Predict Cardiometabolic Protein Expression In Serum Of Covid-19 Patients, James Richard Michels
Th1, Th2, And Th17 Inflammatory Pathways Predict Cardiometabolic Protein Expression In Serum Of Covid-19 Patients, James Richard Michels
Honors Theses
A predominant source of complications in SARS-CoV-2 patients arises from severe systemic inflammation contributed to by Helper T-cell associated cytokines, potentially leading to tissue damage and organ failure. The high inflammatory burden of this viral infection often results in cardiovascular comorbidities. A better understanding of the interaction between the cytokine storm and cardiovascular proteins might inform medical decisions and therapeutic approaches. We hypothesized that all major helper T-cell inflammatory pathways (Helper T 1, Helper T 2 and Helper T 17) synergistically contribute to cardiometabolic pathways in serum of COVID-19 patients, and that both of these factors correlate to COVID-19 severity. …
Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner
Developing New Crutch Tip Design For Overall Increased Stability And Improved Movement On Different Terrains, Lauren Skinner
Honors Theses
Crutches are a mobility assistive device that are often used in various situations, such as post- surgical rehabilitation and recovery after injury. The current crutch tip design that is used on today’s crutches are often unstable and do not provide quality movement on different terrains, such as snow, ice, mud, and wet surfaces. These problems would be solved with a new tip design that could be attached to existing crutches or manufactured with the crutch itself. The team’s solution to this problem is a crutch tip with modular parts. The tip would attach to the shaft of the crutch like …
Increasing Accessibility To Monitoring Ammonia Levels In The Body Through Development Of A Novel Point-Of-Care Breath Ammonia Diagnostic Device, Emily C. Wright, Ashwin M. Sivalingam
Increasing Accessibility To Monitoring Ammonia Levels In The Body Through Development Of A Novel Point-Of-Care Breath Ammonia Diagnostic Device, Emily C. Wright, Ashwin M. Sivalingam
Honors Theses
Hyperammonemia is a life-threatening metabolic condition that is characterized by elevated levels of ammonia concentrations in the blood. Resulting from serious conditions such as chronic kidney disease or liver failure, the limited functions of the liver and kidney lead to an increase in blood urea nitrogen (BUN) within the body. Currently, there are a wide variety of treatments for this condition, ranging from various medications to surgical procedures such as liver transplants. However, there is a lack of variety in diagnostic testing methods to determine a patient’s ammonia levels. In most cases, patients will need to schedule a doctor’s appointment …
Design Of An Implanted Vascular Access Device With A Mechanical Septum, Mallory Ann Moffett, Katherine Rose O'Quinn
Design Of An Implanted Vascular Access Device With A Mechanical Septum, Mallory Ann Moffett, Katherine Rose O'Quinn
Honors Theses
As populations continue to age, their need for medical care continues to rise. This is seen by the large need for implanted vascular devices (IVADs). IVADs are essential for individuals with poor venous access and patients requiring long-term venous delivered drugs. This document will explore the existing IVADs, where they fall short, and where our device, the IrisPort system, works to solve the unmet needs of patients. The IrisPort system is a needle-less port system that allows for repeated venous access without the use of a non-coring needle. Prior art searches have shown that the IrisPort is a novel solution …
Evaluation Of Triple Negative Breast Cancer Tumor Matrix, Alejandra Ham
Evaluation Of Triple Negative Breast Cancer Tumor Matrix, Alejandra Ham
Honors Theses
No abstract provided.
Investigating The Effect Of Polymer Hydrogels On The Antimicrobial Properties Of Activated Carbon Through The Utilization Of Bacterial, Viral, And Parasitic Microorganisms, Zoe Gunter
Honors Theses
Activated carbon (AC) has long been utilized in biomedical applications due to its innate antimicrobial characteristics. However, little is understood about the mechanism of action that allows AC to prohibit the propagation of different pathogen species. To further ascertain these characteristics and how they affect the propagation of pathogens, procedures were designed with bacterial, viral, and parasitic agents which were utilized in conjunction with varying concentrations of polymer hydrogels to examine the antimicrobial efficacy of AC. The studies performed for this thesis were conducted employing coconut-based AC and Noveon® AA-1 Polycarbophil USP or Carbopol® 974P NF hydrogels which, …
Nanoparticle Quantification And Distribution On Fluorescently Coated Angioplasty Balloons, Allison Dobson Zieschang
Nanoparticle Quantification And Distribution On Fluorescently Coated Angioplasty Balloons, Allison Dobson Zieschang
Honors Theses
No abstract provided.
Biomechanical Analysis Of Athletes Sprinting With Varying Degrees Of Resistance, Michaela Ott
Biomechanical Analysis Of Athletes Sprinting With Varying Degrees Of Resistance, Michaela Ott
Honors Theses
Utilizing resistance methods for sprinters is a common approach to their training. In this study, six athletes from the University of Nebraska-Lincoln Women’s Track and Field Team ran a series of sprints using a resistance machine to collect data regarding the change in power output, stride length, level of trunk tilt with respect to the ground, and acceleration throughout a distance of ten meters when different amounts of resistant forces were applied to the athlete. It was hypothesized that as resistance increased, power output would increase, stride length would decrease, the runners would become more horizontal resulting in a larger …
Challenges Of Constructing Entrainment Map For Arbitrary Circadian Models, Yuxuan (Nelson) Wu
Challenges Of Constructing Entrainment Map For Arbitrary Circadian Models, Yuxuan (Nelson) Wu
Honors Theses
The entrainment map, developed by Dr.Diekman and Dr.Bose, is claimed to be a 1-dimensional map that produces a better prediction for phase-locking than methods than the phase response curve for circadian models. In his paper, he constructs the entrainment map for the two-dimensional circadian model, the Novak-Tyson model, and the other two higher-dimensional circadian models. For this thesis, we concentrate on exploring if it is viable to construct the entrainment map for other circadian models that are not included in his paper: the Becker-Weimann model and the Relogio model. In addition, we discuss the challenges of constructing the entrainment map …
Analysis Of The Epidemiology Of Playground-Related Injuries In Relation To Existing Playground Safety Standards: How Should We Address Safe Play?, Drew Filchner
Honors Theses
Play is widely acknowledged to provide children with various physical, emotional, social, and intellectual benefits. However, playgrounds are reported to be the leading location of unintentional recreation injuries to children aged 1-10. Over 185,000 children annually are being treated in emergency departments for playground injuries. These play-related injuries have remained stagnant according to epidemiology studies of the past three decades. Past epidemiological studies for playground injuries have been based on emergency department data, resulting in an underrepresentation of the magnitude of injuries occurring. This study utilizes the unique setting of an entire school district, providing a more comprehensive understanding of …
Orthopedic Anti-Plunging With External Cooling Drill System, David Bates, Nick Muro, Olivia Bresett, Laura Wind
Orthopedic Anti-Plunging With External Cooling Drill System, David Bates, Nick Muro, Olivia Bresett, Laura Wind
Honors Theses
There are 22 million orthopedic surgeries performed globally each year and this number is expected to increase by approximately 6 million by 2022. Within many of these operations, surgeons are required to utilize orthopedic drills to properly insert various implants to facilitate healing within the body. Unfortunately, many of these procedures have complications that result in thermal osteonecrosis or bone plunging. These complications cause the death of bone cells due to heat and the loosening of an implant from drilling through the entirety of the bone, respectively. To help prevent these detrimental issues, we seek to redesign the orthopedic drilling …
Device For Affixation Of Rear-Facing Child Restraint System To Ambulance Cot For Non-Emergent Transport, Troy Kohler, Kendall Rogoff, Matthew Miller, Lily Buchanan
Device For Affixation Of Rear-Facing Child Restraint System To Ambulance Cot For Non-Emergent Transport, Troy Kohler, Kendall Rogoff, Matthew Miller, Lily Buchanan
Honors Theses
During motor vehicle travel it is a near-universal practice to transport infants in a rear-facing car seat, formally known as a child restraint system (CRS). Car seats are subject to heavy regulations, extensive testing, and are safe, secure, and familiar environments for infants. The use of a CRS reduces fatalities associated with motor vehicle collisions by up to 71%. Current devices on the market for pre-hospital infant transport are harness-based and do not utilize these car seats. Aversion to use of these harnesses occurs for a variety of reasons. The device becomes visually unattractive after remaining in storage for long …