Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Exploring Versatile Glycosyltransferases From Microorganisms For Natural Product Biosynthesis, Jie Ren
Exploring Versatile Glycosyltransferases From Microorganisms For Natural Product Biosynthesis, Jie Ren
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
This dissertation is mainly focused on exploring versatile glycosyltransferases from different microorganisms with the purpose of biosynthesizing bioactive natural product glycosides through microbial fermentation. This engineered biosynthesis approach is environmentally friendly, safe, and efficient compared with plant extraction, chemical synthesis, and enzymatic synthesis. Additionally, we applied these characterized glycosyltransferases as efficient biocatalytic tools to produce novel glycosides to expand the chemical repertoire of nature. These novel compounds showed improved water solubility and some of them exhibited enhanced stability and biological activity, which laid the foundation for the development of new therapeutic agents.
In my dissertation research, I have discovered two …