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Biomedical Engineering and Bioengineering

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Selected Works

2004

Articles 1 - 2 of 2

Full-Text Articles in Engineering

Food Based Approaches For A Healthy Nutrition In Africa, Mamoudou Hama Dicko May 2004

Food Based Approaches For A Healthy Nutrition In Africa, Mamoudou Hama Dicko

Pr. Mamoudou H. DICKO, PhD

The latest estimates of the FAO demonstrate the problems of the fight against hunger. These problems are manifested by the ever-increasing number of chronically undernourished people worldwide. Their numbers during the 1999-2001 period were estimated at about 840 million of which 798 million live in developing countries. Sub-Saharan Africa alone represented 198 million of those. In this part of Africa the prevalence of undernourishment ranges from 5-34%, causing growth retardation and insufficient weight gain among one third of the children under five years of age and resulting in a mortality of 5-15% among these children. Malnutrition resulting from undernourishment is …

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Chemogenomic Profiling: Identifying The Functional Interactions Of Small Molecules In Yeast, Patrick Flaherty Jan 2004

Chemogenomic Profiling: Identifying The Functional Interactions Of Small Molecules In Yeast, Patrick Flaherty

Patrick Flaherty

We demonstrate the efficacy of a genome-wide protocol in yeast
that allows the identification of those gene products that functionally
interact with small molecules and result in the inhibition of
cellular proliferation. Here we present results from screening 10
diverse compounds in 80 genome-wide experiments against the
complete collection of heterozygous yeast deletion strains. These
compounds include anticancer and antifungal agents, statins, alverine
citrate, and dyclonine. In several cases, we identified previously
known interactions; furthermore, in each case, our analysis
revealed novel cellular interactions, even when the relationship
between a compound and its cellular target had been well established.
In …

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