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A Dose-Response Curve For The Negative Bias Pressure Of An Intrathoracic Pressure Regulator During Cpr, Charles F. Babbs, Demetris Yannopoulos

Weldon School of Biomedical Engineering Faculty Publications

An intrathoracic pressure regulator (ITPR) is a device that can be added to the external end of an endotracheal tube to create controlled negative airway pressure between positive pressure ventilations. The resulting downward bias of the airway pressure baseline promotes increased venous return and enhanced circulation during CPR and also during hypovolemic shock. In the present study we exercised a mathematical model of the human cardiopulmonary system, including airways, lungs, a 4 chambered heart, great vessels, peripheral vascular beds, and the biomechanics of chest compression and recoil, to determine the relationship between systemic perfusion pressure during CPR and the value …