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Development Of A Mathematical Model To Estimate Intra-Tumor Oxygen Concentrations Through Multi-Parametric Imaging, Chung-Wein Lee, Keith Stantz, Phd
Development Of A Mathematical Model To Estimate Intra-Tumor Oxygen Concentrations Through Multi-Parametric Imaging, Chung-Wein Lee, Keith Stantz, Phd
School of Health Sciences Faculty Publications
Background
Tumor hypoxia is involved in every stage of solid tumor development: formation, progression, metastasis, and apoptosis. Two types of hypoxia exist in tumors—chronic hypoxia and acute hypoxia. Recent studies indicate that the regional hypoxia kinetics is closely linked to metastasis and therapeutic responses, but regional hypoxia kinetics is hard to measure. We propose a novel approach to determine the local pO2 by fusing the parameters obtained from in vivo functional imaging through the use of a modified multivariate Krogh model.
Methods
To test our idea and its potential to translate into an in vivo setting through the use of …