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Modeling Intracranial Fluid Flows And Volumes During Traumatic Brain Injury To Better Understand Pressure Dynamics, Wayne W. Wakeland, James Mcnames, Mateo Aboy, D. Hollemon, Brahm Goldstein

Systems Science Faculty Publications and Presentations

See additional files below for the Presentation.

We describe a computer model of intracranial pressure (ICP) dynamics that evaluates clinical treatment options for elevated ICP during traumatic brain injury (TBI). The model uses fluid volumes as primary state variables and explicitly models fluid flows as well as the resistance, compliance, and pressure associated with each intra - and extracranial compartment (arteries and arterioles, capillary bed, veins, venous sinus, ventricles, and brain parenchyma). The model evaluates clinical events and therapies such as intra - and extra-parenchymal hemorrhage, cerebral edema, cerebrospinal fluid drainage, mannitol administration, head elevation, and mild hyperventilation. The model …