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Biomechanics and Biotransport

University of Arkansas, Fayetteville

Theses/Dissertations

2016

Articles 1 - 2 of 2

Full-Text Articles in Engineering

Development And Analysis Of A Statics And Kinematics Demonstration As A Learning Tool In The Biomechanics Classroom, Bethany D. Knight May 2016

Development And Analysis Of A Statics And Kinematics Demonstration As A Learning Tool In The Biomechanics Classroom, Bethany D. Knight

Biomedical Engineering Undergraduate Honors Theses

This study was done with the objective of determining if students in the biomedical engineering department at the University of Arkansas would gain better understanding of basic biomechanics principles through the implementation of in-class demonstrations. Biomechanics was chosen because it is the first class taken in sequence after the “Introduction to Biomedical Engineering” class. A pre-demonstration survey was administered to gauge how comfortable the students were with the topics on the syllabus. Two demonstrations were done in class and related homework was assigned. The post-semester survey was administered and collected to determine how effective the students felt the presentations to …


Localized Immunotherapy Delivery Using Injectable In Situ Forming Chitosan Hydrogel, Seth Washispack May 2016

Localized Immunotherapy Delivery Using Injectable In Situ Forming Chitosan Hydrogel, Seth Washispack

Biomedical Engineering Undergraduate Honors Theses

Cytokine-based cancer immunotherapies stimulate a host’s immune system to fight cancer. In particular, interleukin-12 (IL-12), a potent pro-inflammatory cytokine, has demonstrated the ability to eliminate tumors in a number of preclinical models. Toxicities associated with the systemic delivery of IL-12 have precluded its use in the clinic. We are developing a novel chitosan-based hydrogel to maintain high local concentrations of cytokines, such as IL-12, in the tumor while minimizing its systemic dissemination. This hydrogel was found to form spontaneously within ten seconds of mixing two proprietary components. To increase the usefulness of the hydrogel, an efficient mixing and delivery system …