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Modeling Viscoelastic Behavior In Compact Bone Through A Distribution Of Collagen D-Spacing: A Finite Element Analysis, Christopher Ha
Modeling Viscoelastic Behavior In Compact Bone Through A Distribution Of Collagen D-Spacing: A Finite Element Analysis, Christopher Ha
Master's Theses
Osteoporosis affects nearly 54 million people in the United States. The cost associated with treatment is estimated to be $19 billion per year and is expected to grow yearly. D-spacing is the staggering of collagen molecules found at the nanoscopic level. Previously thought to have a constant value, recent studies have found that D-spacing has a distribution of values throughout the tissue. As part of an ongoing effort in understanding the mechanisms that are affected by osteoporosis, a finite element model was developed to explore the effects of D-spacing distribution on the viscoelastic material properties of bone tissue. The goal …
Characterization Of Electrophorectic Separations On A Cellulose Paper-Microfluidic Chip, Kyle Robert Fast
Characterization Of Electrophorectic Separations On A Cellulose Paper-Microfluidic Chip, Kyle Robert Fast
Master's Theses
The purpose of this thesis project is to demonstrate the ability to utilize electrophoresis in a cellulose paper microfluidic chip to manipulate charged particles. Materials were selected and a manufacturing protocol was created to successfully apply the electric field onto the paper chip. Experiments were performed to characterize the separation rates for charged, colorimetric dye, Orange G in the membrane as a function of an applied electric field, dye concentration, and distance traveled. The experiments confirmed that the electric field can be applied to the chip and particle separation rates were characterized. Next, the determined rates results were used to …
Development And Validation Of A Tibiofemoral Joint Finite Element Model And Subsequent Gait Analysis Of Intact Acl And Acl Deficient Individuals, Nicholas Czapla
Development And Validation Of A Tibiofemoral Joint Finite Element Model And Subsequent Gait Analysis Of Intact Acl And Acl Deficient Individuals, Nicholas Czapla
Master's Theses
Osteoarthritis (OA) is a degenerative condition of articular cartilage that affects more than 25 million people in the US. Joint injuries, like anterior cruciate ligament (ACL) tears, can lead to OA due to a change in articular cartilage loading. Gait analysis combined with knee joint finite element modeling (FEM) has been used to predict the articular cartilage loading. To predict the change of articular cartilage loading during gait due to various ACL injuries, a tibiofemoral FEM was developed from magnetic resonance images (MRIs) of a 33 year male, with no prior history of knee injuries. The FEM was validated for …
A Finite Element Analysis On The Viscoelasticity Of Postmenopausal Compact Bone Utilizing A Complex Collagen D-Spacing Model, Austin C. Cummings
A Finite Element Analysis On The Viscoelasticity Of Postmenopausal Compact Bone Utilizing A Complex Collagen D-Spacing Model, Austin C. Cummings
Master's Theses
The nanoscale dimension known as D-spacing describes the staggering of collagen molecules, which are fundamental to the biphasic makeup of bone tissue. This dimension was long assumed to be constant, but recent studies have shown that the periodicity of collagen is variable. Given that the arrangement of collagen molecules is closely related to the degree of bone mineralization, recent studies have begun to look at D-spacing as a potential factor in the ongoing effort to battle postmenopausal osteoporosis. The theoretical models presented by previous studies have only opted to model a single collagen-hydroxyapatite period, so the creation of an intricate …