Engineering Commons^™

Building A Biomechanical Model Of A Rat Forelimb, Joshua Nathaniel Eric Mak

Dissertations and Theses

This paper presents a biomechanical model of the rat forelimb to test theories of determining viscoelastic muscle parameters. Several biomechanical models of rat hindlimbs have been developed and have explored the effects of multi-muscle control during locomotion. The forelimb model uses two ball-and-socket joints to model clavicle and scapula movement. A third ball-and-socket joint is used at the shoulder and two hinge joints are used at the elbow and wrist. Scapula motion is further constrained by muscle and spring elements. Each forelimb has 11 degrees of freedom, and 23 Hill-type muscles. The model has been created in Animatlab, which includes …

Silk Cryogels For Microfluidics, Christopher David Hinojosa

Dissertations and Theses

Silk fibroin from silkworm cocoons is found in numerous applications ranging from textiles to medical implants. Its recent adoption as a biomaterial is due to the material's strength, biocompatibility, self-assembling behavior, programmable degradability, optical clarity, and its ability to be functionalized with antibodies and proteins. In the field of bioengineering it has been utilized as a tissue scaffolding, drug delivery system, biosensor, and implantable electrode. This work suggests a new application for porous silk in a microscale chromatography column. We demonstrate in situ cryotropic polymerization of highly porous structures in microscale geometries by freezing aqueous silk with a solvent. The …

Determination Of Systemic Blood Pressure Via Autospectral Analysis Of Oscillometric Data, Eugene Elie Warner

Dissertations and Theses

The currently accepted methods for measuring systemic blood pressure are either highly accurate but invasive in nature or clinically convenient but prone to observer-related errors. A new oscillometric method uses sensitive signal conditioning and sensing equipment with a non-invasive arm cuff to record arterial pulsations. The goal of this study is to establish more reliable criteria for the identification of systolic and diastolic pressures from oscillometric data.

Investigation Of Blood Pressure Measurement Using A Hydraulic Occlusive Cuff, Kusha R. Bhattarai

Dissertations and Theses

This thesis presents an improved oscillotonometric system for the measurement of human blood pressure. The study included:

1. The design of a hydraulic occlusive cuff,

2. The investigation of the wave forms taken from the blood pressure measurements, and

3. The design of a mechanism for the simulation of human blood pressure pulse.

In this study, an experimental system consisting of a rigid shell occlusive cuff, a constant volume displacement pump, a transducer, and a chart recorder was designed and used for data collection.