Engineering Commons^™

Biomechanical Analysis Of Open-Skull High-Rate Traumatic Brain Injury Using Finite Element Mouse Brain Model, Lihong Lu

Electronic Thesis and Dissertation Repository

To better understand traumatic brain injury (TBI), it is necessary to correlate with injuries, which are observed from in vivo laboratory experiments, to brain mechanical responses, which can so far be best predicted by finite element (FE) models. Firstly, a previously validated FE model was improved to investigate the effect of repeated impacts and lateral movements on brain responses to ensure the accuracy and reproducibility of controlled cortical impact (CCI) across different labs. Then, a new FE mouse brain model with the detailed three-dimensional (3D), non-linear vasculature was developed to study how the vasculature affected brain response in CCI and …

Isolated Nucleus Stiffens In Response To Low Intensity Vibration, Joshua Newberg

Boise State University Theses and Dissertations

The nucleus, central to all cellular activity, relies on both direct mechanical input and its molecular transducers to sense and respond to external mechanical stimuli. This response occurs by regulating intra-nuclear organization that ultimately determines gene expression to control cell function and fate. It has long been known that signals propagate from an extracellular environment to the cytoskeleton and into nucleus (outside-in signaling) to regulate cell behavior. Emerging evidence, however, shows that both the cytoskeleton and the nucleus have inherent abilities to sense and adapt to mechanical force, independent of each other. While it has been shown that isolated nuclei …

Katie's Jogger, Megan Guillermo, Erin Wint, Abdullah Sulaiman, Kathryn Mangiaracina

Mechanical Engineering

Edward Robinson is an avid runner who would like to take his daughter on runs. His daughter, Katie, is 100% wheelchair bound and currently does not fit in any commercial joggers on the market. The project team was expected to design, build, and test a custom working prototype of a jogger that the sponsor can use to take his daughter on runs. This entire project was performed over a span of three quarters.

Development And Characterization Of A Biopolymer Direct-Write Process For 3d Microvascular Structures Formation., Xiaoming Fan

Electronic Theses and Dissertations

Engineering of bulk tissues has been limited by the lack of nutrient and waste exchange in these tissues without an adjacent capillary network. To produce microvasculature, a scaffold must be produced that provides temporary mechanical support and stimulate endothelial cell adhesion, growth, and morphogenesis into a vessel. However, current well-established techniques for producing microvasculature, such as electrospinning, are limited since they lack both the precision to control fiber placement in three-dimensional space and the ability to create fiber networks with predefined diameters to replicate the physiological microvascular progression from arteriole to capillary to venule. Our group has developed a “Direct-write” …

Predictive Simulation Of Human Movement And Applications To Assistive Device Design And Control, Vinh Nguyen

Doctoral Dissertations

Predictive simulation based on dynamic optimization using musculoskeletal models is a powerful approach for studying biomechanics of human gait. Predictive simulation can be used for a variety of applications from designing assistive devices to testing theories of motor controls. However, one of the challenges in formulating the predictive dynamic optimization problem is that the cost function, which represents the underlying goal of the walking task (e.g., minimal energy consumption) is generally unknown and is assumed a priori. While different studies used different cost functions, the qualities of the gaits with those cost functions were often not provided. Therefore, this dissertation …

A Novel Fiber Jamming Theory And Experimental Verification, Jared Richard Chafetz

Master's Theses

This thesis developed a novel theory of fiber jamming and experimentally verified it. The theory relates the performance, which is the ratio between the stiff and soft states of a fiber jamming chamber, to three relative design parameters: the ratio of the wall thickness to the membrane inner diameter, the ratio of the fiber diameter to membrane inner diameter, and the number of fibers. These three parameters, when held constant across different chamber sizes, hold the performance constant. To test the theory, three different types of fiber jamming chambers were built in three different sizes. Each chamber was set up …

A Heterogeneous Patient-Specific Biomechanical Model Of The Lung For Tumor Motion Compensation And Effective Lung Radiation Therapy Planning, Parya Jafari

Electronic Thesis and Dissertation Repository

Radiation therapy is a main component of treatment for many lung cancer patients. However, the respiratory motion can cause inaccuracies in radiation delivery that can lead to treatment complications. In addition, the radiation-induced damage to healthy tissue limits the effectiveness of radiation treatment. Motion management methods have been developed to increase the accuracy of radiation delivery, and functional avoidance treatment planning has emerged to help reduce the chances of radiation-induced toxicity. In this work, we have developed biomechanical model-based techniques for tumor motion estimation, as well as lung functional imaging. The proposed biomechanical model accurately estimates lung and tumor motion/deformation …

In Vitro Biomechanical Analyses Of The Pcl And Medial Ligaments Of The Human Knee, Alireza Moslemian

Electronic Thesis and Dissertation Repository

Previous studies have shown that surgical treatments of PCL injuries are not successful in all cases and there is room for improvement. The effectiveness of an isolated PCL reconstruction, in the setting of what actually is a multi-ligament injury, may be inadequate, and therefore the biomechanical contribution of other ligaments in a PCL-deficient knee need to be better understood.

A new apparatus was used to analyze the effect of medial ligaments transection on the kinematics of the PCL-deficient knee during simulated clinical tests and activities of daily living. We observed that the anterior translation of the medial side of the …

System Integration Of C-Arm Robotic Prototype Using Motion Capture Guidance For Accurate Repositioning, Alireza Yazdanshenas

Mechanical Engineering Theses

One of the important surgical tools in spinal surgery is the C-Arm X-ray System. The C-Arm is a large “C” shaped and manually maneuvered arm that provides surgeons and X-ray technicians the ability to take quick quality X-rays during surgery. Because of its five degrees of freedom, the C-Arm can be manually maneuvered around the patient to provide many angles and perspectives, ensuring surgical success.

This system works fine for most surgical procedures but falls short when the C-Arm must be moved out of the way for complicated surgical procedures.

The aim of this thesis is to develop an accurate …

A Novel Method For In Vivo Evaluation Of Finger Kinematics For Analysis Of Activities Of Daily Living, Ahmed M. Tanashi

Electronic Thesis and Dissertation Repository

This thesis examines the development of a six degrees of freedom finger coordinate system that employs electromagnetic tracking to measure finger kinematics. Secondarily, this thesis validated the in vivo finger coordinate system, and is then used to examine range of motion in the fingers in patients with hand osteoarthritis. Lastly, this thesis examines the range of motion of individuals with and without hand arthritis during various activities of daily living, performed with and with joint protection program principles. This study presents a foundation for finger kinematic evaluation and describes a methodology that will be used for larger studies to be …

Investigation Of Fundamental Principles Of Rigid Body Impact Mechanics, Khalid Alluhydan

Mechanical Engineering Research Theses and Dissertations

In impact mechanics, the collision between two or more bodies is a common, yet a very challenging problem. Producing analytical solutions that can predict the post-collision motion of the colliding bodies require consistent modeling of the dynamics of the colliding bodies. This dissertation presents a new method for solving the two and multibody impact problems that can be used to predict the post-collision motion of the colliding bodies. Also, we solve the rigid body collision problem of planar kinematic chains with multiple contacts with external surfaces.

In the first part of this dissertation, we study planar collisions of Balls and …

Computational Analysis And Design Optimization Of Convective Pcr Devices, Jung Il Shu

Mechanical & Aerospace Engineering Theses & Dissertations

Polymerase Chain Reaction (PCR) is a relatively novel technique to amplify a few copies of DNA to a detectable level. PCR has already become common in biomedical research, criminal forensics, molecular archaeology, and so on. Many have attempted to develop PCR devices in numerous types for the purpose of the lab-on-chip (LOC) or point-of-care (POC). To use PCR devices for POC lab testing, the price must be lower, and the performance should be comparable to the lab devices. For current practices with the existing methods, the price is pushed up higher partially due to too much dependence on numerous developmental …

Cooking Hand Multi-Tool, Amanda D. Meares, Amy H. Wilson, Ethan G. Littlejohn, Duania A. Evans

Biomedical Engineering

The purpose of this project was to devise a solution for Jorge Segura, a US Marine who was wounded in Afghanistan and had to have his non-dominant arm amputated above the elbow. His current prosthetic attachments are not suited to cooking tasks, so he needed a way to cook more effectively with either prosthetic attachments or accessibility devices. The main tasks that he needed help with was holding down food on cutting boards and stabilizing pots, pans, and bowls especially when stirring. After background research, exploring commercially available devices, and talking with our challenger, our solution was to design three …

Adapted Trailer Hitching System, Joseph Neil Hearn, Maxwell M. Selna, Maximilian D. Cossalter, Eric B. Ringsrud

Mechanical Engineering

This report highlights the entire design process of an adapted trailer hitching system for Taylor Morris: a navy veteran and quadruple amputee. This begins with problem definition through customer and product research. Objectives are generated after the problem is defined and the boundary of the project is set. This outcome of the project focuses on modifications/improvements to the vehicle side of the problem and leaves the trailers untouched. Engineering specifications are developed to constrain the concept design direction, which ultimately dictates the outcome of the final design. The final design is used as a basis to manufacture a structural prototype …

Sand Foot: A Prosthesis For Walking On Sand, Samantha A. Galicinao, John Dewing, Daniel Dugan Dotson, Christopher Urasaki

Biomedical Engineering

This critical design report describes the product development of a prosthesis for use on sand. Quality of Life Plus (QL+), a national non-profit organization aimed to develop prostheses for veterans and people with disabilities, introduced this project and its accompanying challenger, Sgt. Brady, to Cal Poly’s Interdisciplinary Senior Project class in September 2018. After consulting with Sgt. Brady and QL+ and performing extensive research, the Sand Foot team defined customer requirements and engineering specifications to meet these requirements. Comfortability, durability, and sandproof were key customer requirements. Several conceptual models were brainstormed and a final design was selected based on the …

Investigating Grip Range Of Motion And Force Exerted By Individuals With And Without Hand Arthritis During Functional Tasks And While Swinging A Golf Club, Sara Frances Holland

Electronic Thesis and Dissertation Repository

Hand arthritis is the leading cause of disability in individuals over the age of 50; resulting in dysfunction and pain, making activities of daily living and recreational activities such as golf difficult. Few studies have been conducted on the biomechanical response of individuals with hand arthritis when performing functional activities. This research quantified hand grip movements and strength differences seen in individuals with hand arthritis. Using a video-based motion capture system (Dartfish), a grip limitation of 17.2% (maximum flexion), and 12.7% (maximum extension) was discovered. A wireless finger force measurement system (FingerTPS), was used to show that larger diameter, softer …

How Infant Positioning Impacts Hip Motion And The Associated Implications For Babies With Hip Dysplasia, Lauren Buchele

Biomedical Engineering Undergraduate Honors Theses

Developmental dysplasia of the hip (DDH) refers to a group of disorders, ranging from slight instability (Grades 1-3) to a severe dislocation (Grade 4) of the femoral head from the acetabulum [1]. In order to treat DDH in infants, a reduction procedure and the use of a lower body harness to secure the hip joint as the bones and ligaments re-form properly is typically prescribed. The Pavlik Harness is currently the “gold-standard” orthopedic device used to place hips in proper positioning. However, little research has been reported on the biomechanical affects during use of these device types.

Although the Pavlik …

Factors Affecting Patellar Mechanics And Bone Strain In Patients With Crouch Gait, Erika Ramirez

Boise State University Theses and Dissertations

Crouch gait is a musculoskeletal impairment that results in higher than normal stresses at the patellofemoral (PF) joint that can lead to instances of anterior knee pain and loss of ambulation. The impact of commonly implemented surgical procedures to correct for crouch gait can be quantified by evaluating stresses and underlying patellar bone strain during a gait cycle. The aims of this thesis work were (1) to analyze changes in PF mechanics and patellar bone strain between pre- and postoperative conditions; (2) to quantify the variability of predicted patellar strain due to different kinematic/loading profiles or patellar material properties; and …

Danny’S Recumbent Bike Accessibility Device Final Design Report, Joseph J. Lee, Huy Nguyen, Jack Mcatee, John Kulick

Mechanical Engineering

The purpose of this document is to fully define our design solution and explain our manufacturing and testing results. Our project’s goal is to find a way to allow Danny Knutson, a retired Navy pilot and incomplete quadriplegic with limited use of his arms and an impaired sense of balance, to enter and exit his recumbent tricycle without any discomfort for him or his aide. We completed multiple interviews with Danny, patent research, existing product research, and other technical literature research in order to fully understand the problem. We synthesized this information to create a concrete list of customer wants …

Final Design Report For The Bioburden Pre-Cleaning Device And Dr. Mark Rasnake At The University Of Tennessee Medical Center, Katherine Elizabeth Stiles, Megan Pitz, Kayla Franklin, Simran Dayal, Austin Bullock

Chancellor’s Honors Program Projects

No abstract provided.

The Effects Of Bone Morphogenic Protein 2 On The Viability And Proliferation Of Dental Pulp Stem Cell Isolates, Joseph Cinelli

UNLV Theses, Dissertations, Professional Papers, and Capstones

Growth factor is an umbrella term used to describe a signaling molecule present in organisms that serves the purpose of influencing a stimulatory or inhibitory response from the target cell it acts on. Growth factors are categorized and classified by the types of tissues they act on and the cellular responses they illicit. For example, there are growth factors that act primarily in connective tissue on fibroblasts and they are aptly classified as the fibroblast growth factor family. Similarly, there is another family of growth factors that act on bone forming cells, among others, and they are known as bone …

The Affective Perceptual Model: Enhancing Communication Quality For Persons With Pimd, Jadin Tredup

UNLV Theses, Dissertations, Professional Papers, and Capstones

Methods for prolonged compassionate care for persons with Profound Intellectual and Multiple Disabilities (PIMD) require a rotating cast of import people in the subjects life in order to facilitate interaction with the external environment. As subjects continue to age, dependency on these people increases with complexity of communications while the quality of communication decreases. It is theorized that a machine learning (ML) system could replicate the attuning process and replace these people to promote independence. This thesis extends this idea to develop a conceptual and formal model and system prototype.

The main contributions of this thesis are: (1) proposal of …

Quantification Of Myocardial Mechanics In Left Ventricles Under Inotropic Stimulation And In Healthy Right Ventricles Using 3d Dense Cmr, Zhan-Qiu Liu

Theses and Dissertations--Mechanical Engineering

Statistical data from clinical studies indicate that the death rate caused by heart disease has decreased due to an increased use of evidence-based medical therapies. This includes the use of magnetic resonance imaging (MRI), which is one of the most common non-invasive approaches in evidence-based health care research. In the current work, I present 3D Lagrangian strains and torsion in the left ventricle of healthy and isoproterenol-stimulated rats, which were investigated using Displacement ENcoding with Stimulated Echoes (DENSE) cardiac magnetic resonance (CMR) imaging. With the implementation of the 12-segment model, a detailed profile of regional cardiac mechanics was reconstructed for …

The Influence Of Size And Progression Of Intra-Cerebral Hematoma On The Lateral Ventricles, Muhammad J. Ashraf

Dissertations and Theses

Cerebrovascular diseases like intra cerebral hemorrhage are quite deadly and may disturb functioning of the brain, expanding and resulting in formation of an intra cerebral hematoma(ICH). It is imperative to comprehend how hematoma and its expansion inside the brain endangers human life. One of the influences of an ICH inside brain tissue is on the Lateral Ventricles(LV). When the hemorrhage occurs close enough to the lateral ventricles, filled with cerebrospinal fluid(CSF), it disrupts the balance of fluid in LV. A minor pressure change in LV can negatively influence the production of CSF as well as an increase in intracranial pressure. …

The Influence Of 3d Porous Chitosan-Alginate Biomaterial Scaffold Properties On The Behavior Of Breast Cancer Cells, Minh-Chau N. Le

Honors Undergraduate Theses

The tumor microenvironment plays an important role in regulating cancer cell behavior. The tumor microenvironment describes the cancer cells, and the surrounding endothelial cells, fibroblasts, and mesenchymal stem cells, along with the extracellular matrix (ECM). The tumor microenvironment stiffens as cancer undergoes malignant progression, providing biophysical cues that promote invasive, metastatic cellular behaviors. This project investigated the influence of three dimensional (3D) chitosan-alginate (CA) scaffold stiffness on the morphology, growth, and migration of green fluorescent protein (GFP) – transfected MDA-MB-231 (231-GFP) breast cancer (BCa) cells. The CA scaffolds were produced by the freeze casting method at three concentrations, 2 wt%, …

Experimental Analysis Of Protective Headgear Used In Defensive Softball Play, John Scott Strickland

UNF Graduate Theses and Dissertations

Every year in the United States, an estimated 1.6 to 3.8 million people sustain sports-related traumatic brain injuries (TBIs), with an appreciable number of these injuries coming from the sport of softball. Several studies have analyzed the impact performance of catcher’s masks within the context of baseball; however, virtually no studies have been performed on fielder’s masks within the context of softball. Thus, the main objective of the present work was to evaluate the protective capabilities of softball fielder’s masks. To better understand the injury mechanisms and frequency associated with softball head/facial injuries, epidemiological data from a national database was …

Estimation Of Multi-Directional Ankle Impedance As A Function Of Lower Extremity Muscle Activation, Lauren Knop

Dissertations, Master's Theses and Master's Reports

The purpose of this research is to investigate the relationship between the mechanical impedance of the human ankle and the corresponding lower extremity muscle activity. Three experimental studies were performed to measure the ankle impedance about multiple degrees of freedom (DOF), while the ankle was subjected to different loading conditions and different levels of muscle activity. The first study determined the non-loaded ankle impedance in the sagittal, frontal, and transverse anatomical planes while the ankle was suspended above the ground. The subjects actively co-contracted their agonist and antagonistic muscles to various levels, measured using electromyography (EMG). An Artificial Neural Network …

Estimation And Prediction Of The Human Gait Dynamics For The Control Of An Ankle-Foot Prosthesis, Guilherme Aramizo Ribeiro

Dissertations, Master's Theses and Master's Reports

With the growing population of amputees, powered prostheses can be a solution to improve the quality of life for many people. Powered ankle-foot prostheses can be made to behave similar to the lost limb via controllers that emulate the mechanical impedance of the human ankle. Therefore, the understanding of human ankle dynamics is of major significance. First, this work reports the modulation of the mechanical impedance via two mechanisms: the co-contraction of the calf muscles and a change of mean ankle torque and angle. Then, the mechanical impedance of the ankle was determined, for the first time, as a multivariable …

Computational Fluid Dynamics Investigation Of A Novel Hybrid Comprehensive Stage Ii Operation For Single Ventricle Palliation, Marwan Hameed

Electronic Theses and Dissertations

Hypoplastic left heart syndrome (HLHS) is a type of heart defect where the left ventricle is underdeveloped or not developed, resulting in only a single functioning right ventricle. Approximately 7.5% of patients with congenital heart disease are born with a single ventricle (SV) which is accompanied by a spectrum of other malformations such as atrophied ascending aorta, atrial septal defects, and ventricular septal defects (VSD). The existing three-hybrid staged surgical approach serving as a palliative treatment for this anomaly entails multiple complications and achieves a survival rate of only 50%. To reduce the trauma associated with the second stage of …

Probing The Influence Of Cx43 And Glucose On Endothelial Biomechanics, Md Mydul Islam

Electronic Theses and Dissertations

Endothelial cells (ECs) form the innermost layer of all vasculature and constantly receive both biochemical and biomechanical signals, yielding a plethora of biomechanical responses. In response to various biochemical or biomechanical cues, ECs have been documented to generate biomechanical responses such as tractions and intercellular stresses between the cell and substrate and between adjacent cells in a confluent monolayer, respectively. Thus far, the ability of endothelial tight junctions and adherens junctions to transmit intercellular stresses has been actively investigated, but the role of gap junctions is currently unknown. In addition, there is no report of the independent influence of hyperglycemia …