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Full-Text Articles in Engineering
Development Of Multifunctional Drug Delivery Systems For Locoregional Therapy, Xinyi Li
Development Of Multifunctional Drug Delivery Systems For Locoregional Therapy, Xinyi Li
Electronic Thesis and Dissertation Repository
Locoregional treatment is the specific delivery of therapeutics to their desired sites of action with minimized systemic adverse effects. In this approach, drug is administered through topical instillation, inhalation, intra-lesional or intra-arterial injection. Decades of experience in locoregional treatment have delivered meaningful benefits to patients with localized diseases (e.g., osteoarthritis, ocular disorders and liver cancers). However, improvements are required for this type of treatment to be more effective. For transarterial chemoembolization (TACE) therapy of hepatocellular carcinoma (HCC), the most current approaches do not allow repeat treatment as the drug delivery vehicle is not degradable. In addition, image contrast agents for …
3d Printed Polypyrrole Scaffolds For Ph Dependent Drug Delivery With Applications In Bone Regeneration, Matthew T. Lawrence
3d Printed Polypyrrole Scaffolds For Ph Dependent Drug Delivery With Applications In Bone Regeneration, Matthew T. Lawrence
Electronic Thesis and Dissertation Repository
Areas of large bone loss are typically healed using autologous bone grafts, seen as the gold standard of care. These materials have a complication rate of 10–40% during harvesting and are limited by the quantity available; therefore the use of 3D printed polymer scaffolds as bone graft alternatives are proposed. Polypyrrole (PPy) is a biocompatible electroactive polymer that has metal-like electrical properties that can be harnessed to hold and release charged drug molecules, triggered by a change in pH. pH fluctuations are seen inside the human body in areas of bone regrowth, which would act as the triggering mechanism for …
Immunomodulatory Biomaterials For Cancer Immunotherapy, Larry Donnell Stokes Jr
Immunomodulatory Biomaterials For Cancer Immunotherapy, Larry Donnell Stokes Jr
Honors Theses
Cancer immunotherapy has become an effective treatment in the toolbox of oncologists. Immunotherapy offers a less toxic alternative to standard cancer treatments such as chemotherapy and can have prolonged curative effects to decrease cancer recurrence. Today, many drugs and biological agents have been developed that target the immune system and elicit an antitumor/cancer response. These agents are known collectively as cancer immunotherapies. While immunotherapies have radically improved treatment outcomes for many cancer patients, there are drawbacks to using these treatments. Immunotherapy treatments have poor clinical responses in patients with tumors that lack immunogenicity. Some of the treatments also pose a …