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Amino-protected glutamic acid; biodegradation; depolymerization; Rhizopus delemar lipase; Michaelis–Menten; polyesters
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Full-Text Articles in Engineering
Michaelis–Menten Kinetics For Enzymatic Depolymerization Of A Linear Polyester Synthesized From Z-Protected Glutamic Acid, R M. Tadros, Hossein Noureddini, Delmar C. Timm
Michaelis–Menten Kinetics For Enzymatic Depolymerization Of A Linear Polyester Synthesized From Z-Protected Glutamic Acid, R M. Tadros, Hossein Noureddini, Delmar C. Timm
Papers in Biomaterials
A biodegradable polyester resin was polymerized from N-benzyloxycarbonyl- L -glutamic acid and ethylene glycol. Rhizopus delemar lipase was used as a biocatalyst for the rupture of ester bonds during the hydrolysis studies. Depoly-merization was observed to followa Michaelis–Menten mechanism, with the maximumrate of monomer formation dP/dtmax = 1.12 x 10-8 mol/s and the rate constant Km x 2.03 x 10-4 mol. Subject to initial conditions described by the most probable distribution and Michaelis–Menten–type depolymerization rate expressions, population density distribu-tion dynamics of the polymeric molecules that formed the resin were explicitly described using a deterministic ap-proach.