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Engineering Graphene Oxide-Based Nanostructures For Dna Sensors, Aditya Balaji

Electronic Thesis and Dissertation Repository

Various nanostructures have been explored in DNA biosensors to convert the hybridization of DNA sequences to easily measurable processes, including optical, mechanical, magnetic, or electrochemical process. In this thesis, graphene oxide, a two-dimensional nanostructure, is applied in quenching the fluorescence of a core-shell nanoparticles modified with targeted DNA sequences. The core-shell nanoparticles, iron oxide (Fe₃O₄) core, and fluorescent silica (SiO₂) shell, were produced through a wet chemical process which can directly link to a targeted DNA sequence (DNA-t), and the graphene oxide nanosheets were produced by the oxidation of graphite. In the meantime, …