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High-Throughput Fabrication Of Drug-Loaded Core-Shell Tablets With Adjustable Release Profiles From Surface-Erodible And Photocrosslinkable Polyanhydrides, Armin Geraili Nejadfomeshi

Electronic Thesis and Dissertation Repository

Controlled-release tablets enhance the effectiveness of therapies for various clinical conditions. Photocrosslinkable polyanhydrides that undergo surface erosion were recently introduced as suitable materials for manufacturing tablets with tunable release profiles. However, their erosion behavior has not been comprehensively studied. In this thesis, the erosion kinetics of photocrosslinkable polyanhydrides was studied by exploring the impact of different parameters (the polymer composition and geometry, as well as the temperature, pH, and shaking rate of the solution during the in vitro experiments) on their mass loss profiles, followed by a release kinetic model fitting. The results indicate that the temperature was the only …