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Articles 1 - 11 of 11
Full-Text Articles in Engineering
Nanocellulose Based Foams For Low-Cost Disposable Medical Applications, Dominic Kugell
Nanocellulose Based Foams For Low-Cost Disposable Medical Applications, Dominic Kugell
Electronic Theses and Dissertations
Polyurethane foams have been a staple material for their use in medical positioners, such as post-surgery elevation pillows as well as specific tailored positioners for their use during surgery. Polyurethane foams are preferred because of their lower cost compared to other petroleum derived foams, their versatility, and suitable mechanical properties. However, the environmental impact, including both cost and perception, of these foams is immense. Therefore, alternatives are being explored with biopolymers emerging as a promising class of materials. Cellulose is one such polymer that has recently demonstrated desirable properties. In this study, cellulose nanofibrils (CNF), a household foaming agent, and …
The Influence Of Processing And Additives On Cellulose Nanofiber Properties For Orthopedic Application, Mitchell P. Chesley
The Influence Of Processing And Additives On Cellulose Nanofiber Properties For Orthopedic Application, Mitchell P. Chesley
Electronic Theses and Dissertations
Current orthopedics are separated into three different classes of materials, metals, polymers, and ceramics. While these devices have had success throughout the years they are not without their faults. Metallic devices for example are usually extraordinarily stiff when compared with the surrounding bone. This difference in stiffness induces localized stress-shielding promoting cortical atrophy, which can lead to osteoporosis. Polymers while having the capacity of being biodegradable and bioabsorbable also have the potential to incite localized demineralization and weakness in surrounding bone. A result of breakdown byproducts not efficiently being evacuated from the area, which additionally acts as catalysts expediating the …
Developing And Characterizing A Novel Tempo Cnf Hydrogel Adjuvant And Delivery System For Aquatic Vaccines, Kora Kukk
Electronic Theses and Dissertations
Aquaculture is a large part of the food production sector which is greatly expanding. One of the largest losses in aquaculture is due to pathogens. Current solutions for protecting farmed finfish from pathogens can be very expensive with variable efficiency. Current disease prevention strategies include vaccination. Types of vaccines include immersion vaccines, feed vaccines, and injectable vaccines. The most popular solution is oil-based injectable vaccines due to its protection. However, the oil-based adjuvant used in most of these formulations causes adverse reactions in the fish including reduced growth. These vaccines require multiple administrations throughout the fish’s lifetime causing unwanted handling …
Continuous, Non-Destructive Detection Of Surface Bacterial Growth With Bioinspired Vascularized Polymers, Brandon Dixon
Continuous, Non-Destructive Detection Of Surface Bacterial Growth With Bioinspired Vascularized Polymers, Brandon Dixon
Electronic Theses and Dissertations
Reducing or eliminating bacteria on surfaces is vital for medical devices, drinking water quality, and industrial processes. Evaluating surface bacterial growth at buried interfaces can be problematic due to the time-consuming disassembly process required for obtaining standard surface samples. In this work, a continuous, non-destructive, and reusable method was developed to detect surface bacterial growth at buried interfaces. Inspired by vascular systems in nature that permit chemical communication between the surface and underlying tissues of an organism, bacterial-specific signals diffusing from cells on the surface were detected in channels filled with an inert carrier fluid embedded in a polymer matrix. …
Nanocellulose Conduits For Enhanced Regeneration Of Peripheral Nerve Injuries, Nicklaus R. Carter
Nanocellulose Conduits For Enhanced Regeneration Of Peripheral Nerve Injuries, Nicklaus R. Carter
Electronic Theses and Dissertations
Peripheral neuropathy is estimated to afflict 20 million people in the United States. Most cases of neuropathy result from physical injuries and trauma arising from automobile accidents and war. Peripheral nerves have the intrinsic ability to regenerate over time, bridging the injury gap. However native regeneration is limited to a distance of only a few millimeters. Current methods utilized to assist in the regeneration of peripheral nerves over distances exceeding those amenable to native repair include nerve autografts and allografts, and implantation of conduits. Nerve autografts are regarded as the most effective method but require a second surgical site to …
Handling And Manipulation Of Water- And Air- Borne Biological Samples Using Liquid-Infused Surfaces, Daniel P. Regan
Handling And Manipulation Of Water- And Air- Borne Biological Samples Using Liquid-Infused Surfaces, Daniel P. Regan
Electronic Theses and Dissertations
Research on novel materials to handling water- and airborne samples for biological threats analysis is in great demand due to the COVID-19 pandemic. Work conducted on a new field of material science, called liquid-infused surfaces, demonstrate strong potential for the handling and manipulation of biological samples. As a result of the field’s infancy, only a limited number of studies have explored how liquid-infused surfaces can apply droplet manipulation strategies to address real-world problems. Presented in this dissertation are two platforms that leverage liquid-infused surfaces to address the challenges associated with handling water- and airborne biological samples. When dealing with waterborne …
Characterization Of Nano-Cellulose Based Composites For Biomedical Applications, Mitchell P. Chesley
Characterization Of Nano-Cellulose Based Composites For Biomedical Applications, Mitchell P. Chesley
Electronic Theses and Dissertations
The number of orthopedic surgeries performed globally has steadily increased over the past decade due to the standardization of procedures as well as technological advancements. During this time orthopedic devices have been composed predominantly of metals, such as Titanium, Vanadium, Molybdenum, and Stainless steel, as well as their alloys, due to the high strength and durability of these materials. However, metals may, in fact, be suboptimal for orthopedic devices. For example, metals exhibit Young’s modulus much greater than the surrounding bone, inducing localized stress-shielding promoting cortical atrophy, which can lead to osteoporosis. In recent years polymers have been successfully explored …
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Design, Construction And Application Of A Home-Built, Two-Photon Microscope, William P. Breeding
Electronic Theses and Dissertations
Two-photon microscopy (TPM) is a powerful, versatile imaging modality for the study of biological systems. This thesis overviews the relevant physics involved in TPM, design considerations and process of constructing a home-built, two-photon microscope, and provides a set of procedures to operate the system. Furthermore, this work explores several applications of TPM through the study of single-cell metabolism and imaging the cellular-material interface. Explored in particular depth was the imaging of cellulose nanofiber (CNF) materials, with the goal of understanding the three-dimensional nature of fibroblast cell growth when embedded within the materials. This work uncovered several optical properties of CNF, …
Nanocellulose Fibers As A Potential Material For Orthopedic Implantation Application, David Gregg Holomakoff
Nanocellulose Fibers As A Potential Material For Orthopedic Implantation Application, David Gregg Holomakoff
Electronic Theses and Dissertations
The field of biomaterials is of immense importance and will continue to grow and develop in the coming years. Novel materials, as well as new approaches for use of existing materials, are sought after now more than ever. Current metal orthopedic implants have an over engineered stiffness and Young’s modulus, causing a phenomenon called stress shielding. Metal implants absorb the majority of force typically exerted on bone and the osteocytes within. When osteocytes fail to sense mechanical forces bones become less dense and weaken, causing possible fracture and other complications. A new orthopedic material is needed matching Young’s modulus of …
A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox
A Multi-Channel 3d-Printed Bioreactor For Evaluation Of Growth And Production In The Microalga Dunaliella Sp, Cristian A. Cox
Electronic Theses and Dissertations
We explored the capabilities of additive manufacturing using a photo-cured jetted material 3D printer to manufacture a milli-microfluidic device with direct application in microalgae Dunaliella sp growth and intracellular compounds biosynthesis tests. A continuous microbioreactor for microalgae culture was CAD designed and successfully built in 1 hour and 49 minutes using black photopolymer cured by UV and a support material. The microreactor was made up of 2 parts including the bioreactor itself and a microchannel network for culture media fluids and microalgae. Both parts were assembled to form a single unit. Additional optical and auxiliar components were added. An external …
Modeling The Costs Of Cellulosic Biofuel, Maxwell Berube
Modeling The Costs Of Cellulosic Biofuel, Maxwell Berube
Honors College
This thesis seeks to establish the private and external costs of the production of cellulosic biofuel from woody biomass. A model is presented which explores the economic feasibility of a firm producing this biofuel using a particular process. Specifically, it examines the input costs including the external costs of transportation, the external cost of pollutants produced by the firm, and potential cost reductions that may be applied as a result of learning from accumulated experience. In order to evaluate the feasibility of the plant, a spreadsheet model is built and a Monte Carlo simulation is run in order to evaluate …