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Oxidase-Coupled Amperometric Glucose And Lactate Sensors With Integrated Electrochemical Actuation System, Jongwon Park, Chang-Soo Kim, Minsu Choi
Oxidase-Coupled Amperometric Glucose And Lactate Sensors With Integrated Electrochemical Actuation System, Jongwon Park, Chang-Soo Kim, Minsu Choi
Electrical and Computer Engineering Faculty Research & Creative Works
Unpredictable baseline drift and sensitivity degradation during continuous use are two of the most significant problems of biosensors including the amperometric glucose and lactate sensors. Therefore, the capability of on-demand in situ calibration/diagnosis of biochemical sensors is indispensable for reliable long-term monitoring with minimum attendance. Another limitation of oxidase enzyme-based biosensors is the dependence of enzyme activity on the background oxygen concentration in sample solution. In order to address these issues, the electrolytic generation of oxygen and hydrogen bubbles were utilized 1) to overcome the background oxygen dependence of glucose and lactate sensors and 2) to demonstrate the feasibility of …
Automated Oxidase-Coupled Amperometric Microsensor With Integrated Electrochemical Actuation System For Continuous Sensing Of Saccharoids, Yadunandana Yellambalase, Jongwon Park, Chang-Soo Kim, Minsu Choi, Nohpill Park, Fabrizio Lombardi
Automated Oxidase-Coupled Amperometric Microsensor With Integrated Electrochemical Actuation System For Continuous Sensing Of Saccharoids, Yadunandana Yellambalase, Jongwon Park, Chang-Soo Kim, Minsu Choi, Nohpill Park, Fabrizio Lombardi
Electrical and Computer Engineering Faculty Research & Creative Works
Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. To address this deficiency, a novel needle-type biosensor system with fully automated operations is being developed, in which a novel oxidase-coupled amperometric sensor with oxygen depleting/generating actuator is interfaced with an electrochemical instrument and a perfusion system. Labview virtual instrument has been also developed to oversee the …