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Substrate Stiffness And Adhesivity Influence Neuron Axonal Growth, Eben Grant Estell
Substrate Stiffness And Adhesivity Influence Neuron Axonal Growth, Eben Grant Estell
Honors College
The nervous system is a complex organ system that coordinates all of the actions of an animal. The transmission of signals between different body parts by this organ system allows the body to function as a whole and interact with the external environment. It is clear then that the nervous system is integral to the function and survival of those organisms in which it has developed; and yet much is lacking in our understanding of the system’s key constituents: neuronal cells or, neurons. In satisfaction of the Honors Thesis, this research investigates how certain conditions of the extracellular environment …
Development Of Porous Polymeric Implants For Use In Orthopedic Research And Development Applications, Alexander Caddell
Development Of Porous Polymeric Implants For Use In Orthopedic Research And Development Applications, Alexander Caddell
Honors College
Current orthopedic implants comprised of plastic, ceramic, or metal alloys are susceptible to surface degradation at the implant-implant interface. The resulting microscopic fragments cause tissue irritation that can lead to osteolysis. In addition, existing percutaneous implants, such as pins used to stabilize fractures, are prone to bacterial infections due to the inability of the surrounding soft tissue to adhere to the implant and form a biologic seal. The goal of this Honors Thesis was to develop porous polymeric implants for orthopedic research and development applications that improve upon current designs in an attempt to remedy the issues detailed above. A …