Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Nonlinear Optical Microscopy Of Murine Abdominal Aortic Aneurysm, Katherine E. Wilson, Alexa A. Yrineo, Amelia J. Adelsperger, Hilary D. Schroeder, Delong Zhang, Jesse Zhang, Chien-Sheng Liao, Frederick W. Damen, Ji-Xin Cheng, Evan H. Phillips, Craig J. Goergen
Nonlinear Optical Microscopy Of Murine Abdominal Aortic Aneurysm, Katherine E. Wilson, Alexa A. Yrineo, Amelia J. Adelsperger, Hilary D. Schroeder, Delong Zhang, Jesse Zhang, Chien-Sheng Liao, Frederick W. Damen, Ji-Xin Cheng, Evan H. Phillips, Craig J. Goergen
The Summer Undergraduate Research Fellowship (SURF) Symposium
Abdominal aortic aneurysm (AAA) is a cardiovascular disease characterized by dilation and weakening of the vessel wall. AAA rupture is responsible for approximately 14,000 deaths annually in the United States [1]. Nonlinear optical (NLO) microscopy presents new possibilities for analyzing AAA tissue samples from murine models. Common NLO techniques are two-photon excitation fluorescence (TPEF), which detects the intrinsic autofluorescent properties of elastin, and second-harmonic generation (SHG), which is specific for collagen fibrils. Elastin and collagen, two major extracellular matrix components, help the aortic wall withstand internal pressure. Murine AAAs were created through 1) subcutaneous continuous systemic infusion of angiotensin II …