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Characterization And Analysis Techniques Of A Dynamic In Vitro Blood-Brain Barrier Model, Ryan Everett Woodhouse
Characterization And Analysis Techniques Of A Dynamic In Vitro Blood-Brain Barrier Model, Ryan Everett Woodhouse
Biomedical Engineering
The blood-brain barrier (BBB) is responsible for maintaining the sensitive environment required by the brain. Although the BBB is necessary for proper functioning of the brain, it acts as an obstacle for doctors attempting to treat neurological disease. For a drug to act upon the brain, it must first pass through the discriminating BBB. For this reason, much research has been performed in recent years in order to create an in vitro model of the BBB on which drugs targeted for the central nervous system may be tested. The main goal of this project is to create an in vitro …
Can Spr Be Used To Interrogate The Double Layer Of Nacl, Brandon Kawula
Can Spr Be Used To Interrogate The Double Layer Of Nacl, Brandon Kawula
Biomedical Engineering
Solutions of reagent grade salt .1, .01, .001, .0001, .00001M were run through a SPR to see if SPR had enough resolution to detect the formation of the electric double layer. We found that NaCl did in fact return a detectable signal. The signal shape seems to depend on concentration. While more study may need to be done to get definite information it looks like SPR can interrogate the double layer.