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- Biosensor (1)
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- Carbon paste electrodes (1)
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- Epilepsy (1)
- Incontinence (1)
- Inflammation (1)
- Metallothionein (1)
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- Urinary incontinence (UI) (1)
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Articles 1 - 4 of 4
Full-Text Articles in Engineering
Towards In Situ Measurements Of Platinum Dissolution Using Metallothionein-Based Biosensor, Stephanie Cernera, Hyowon Lee
Towards In Situ Measurements Of Platinum Dissolution Using Metallothionein-Based Biosensor, Stephanie Cernera, Hyowon Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
Platinum-based (Pt) electrodes are used ubiquitously in neurostimulation for their high charge capacity and safety. However, Pt electrodes are known to dissolve during stimulation in the presence of chloride (Cl) to form Pt-Cl byproducts. These byproducts may have deleterious effects on surrounding tissue by preventing cell division and causing apoptosis. Several studies have quantified the amount of neurostimulation-induced Pt dissolution in vivo using various analytical methods; however, these approaches require disruptive sampling of tissue. Periodic measurements from a stimulating electrode using an in situ sensor may provide additional insights into Pt dissolution process. To create the sensor for detecting Pt …
Implantable Device For Wireless Regulation Of The Bladder Through Pelvic Nerve Stimulation, Kelsey C. Bayer, Chris Quinkert, Pedro Irazoqui
Implantable Device For Wireless Regulation Of The Bladder Through Pelvic Nerve Stimulation, Kelsey C. Bayer, Chris Quinkert, Pedro Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
Urinary incontinence (UI) is the involuntarily urination that usually effects older people or is the result of an injury. UI affects more than eleven million people and the cost of incontinence management in the United States in 2000 was $19.5 billion. Where conventional physical therapies have failed, pelvic nerve stimulation is a promising form of regulating the bladder long term. Piezoresistive pressure sensors consist of two variable resistance values and two known resistance values that are represented on a daughterboard. This unknown resistance represents the change in pressure. The filling and voiding of the bladder was characterized through acute surgeries. …
An Implantable Device To Regulate Urination Through Deep Brain Stimulation, Jesse E. Bucksot, Muhammad A. Arafat, Pedro Irazoqui
An Implantable Device To Regulate Urination Through Deep Brain Stimulation, Jesse E. Bucksot, Muhammad A. Arafat, Pedro Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
Urinary Incontinence (UI) is a disease in which patients lose control of their bladder. It is particularly common in elderly women having a prevalence of as much as 30% to 50% [1]. Many of these patients are left without successful treatment. A recent study has shown a new option for treatment that consists of deep brain stimulation (DBS) at a site known as the periaqueductal gray (PAG) [2, 3]. To test the effectiveness of this treatment, chronic stimulation of the PAG should be used in animals to see if it can reliably prevent micturition in the long term. A device …
The Effects Of Vagus Nerve Stimulation On Neuroinflammation In Epilepsy, Elizabeth A. St. Clair, Gabriel O Albors, Pedro Irazoqui Dr., Amy Brewster
The Effects Of Vagus Nerve Stimulation On Neuroinflammation In Epilepsy, Elizabeth A. St. Clair, Gabriel O Albors, Pedro Irazoqui Dr., Amy Brewster
The Summer Undergraduate Research Fellowship (SURF) Symposium
Epilepsy is a neurological disorder characterized by chronic, unexplainable seizures. Recurring epileptic seizures are associated with long-term structural damage and cognitive deficits, and can even lead to sudden, unexplainable death. Approximately 30% of epilepsy cases are not responsive to medication. Epileptic seizures often induce inflammation in the brain and may increase the frequency of future seizures, resulting in a detrimental cycle. Vagus nerve stimulation (VNS) is a non-pharmaceutical treatment method for epilepsy that has been shown to reduce inflammation in peripheral pathways. The role of VNS in the modulation of neuroinflammation has yet to be demonstrated experimentally. To explore this, …