Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Thin-Film Sol-Gel As Controlled Delivery Platform For Neural Microelectrodes, Margaret A. Harden, Matthew D. Mcdermott, Kevin J. Otto
Thin-Film Sol-Gel As Controlled Delivery Platform For Neural Microelectrodes, Margaret A. Harden, Matthew D. Mcdermott, Kevin J. Otto
The Summer Undergraduate Research Fellowship (SURF) Symposium
Long-term efficacy of neural implantation devices is a persisting challenge in neural engineering and rehabilitation. Upon implantation of a neural device, the foreign body response (FBR) is triggered and glial cells form a sheath around the electrode array. This sheath isolates the array from the rest of the brain both mechanically and electrically. Tetramethyl orthosilicate (TMOS), a thin-film polymer, has been shown to not negatively impact the impedance and charge-carrying capacity, as well as offer a controlled delivery method to deliver pharmaceuticals to mitigate inflammation without significant effect to device design. Using an in vitro protein delivery model to analyze …