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Tissue Engineering Scaffolds With Enhanced Oxygen Delivery Using A Cyclodextrin Inclusion Complex, Tierney Gb Deluzio
Tissue Engineering Scaffolds With Enhanced Oxygen Delivery Using A Cyclodextrin Inclusion Complex, Tierney Gb Deluzio
Tierney GB Deluzio
The development of a strategy to improve oxygen delivery to cells seeded on scaffolds is essential for the success of tissue engineering applications. The focus of this work was to explore the application of cyclodextrin inclusion complexes (CD:ICs) with perfluorocarbons as oxygen carriers. CD:ICs were prepared from alpha-cyclodextrin and perfluoroperhydrophenanthrene via co-precipitation, paste mixing, and dry mixing complexation techniques. Characterization indicated that paste mixing at a 2:1 host:guest ratio was the most effective method for complexation between the parent molecules. The CD:ICs were then successfully incorporated in 3D fibrous mats via electrospinning with poly(carbonate urethane) and polycaprolactone as biostable and …