Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
Predicting Enzyme Targets For Optimization Of Metabolic Networks Under Uncertainty, David Christopher Flowers
Predicting Enzyme Targets For Optimization Of Metabolic Networks Under Uncertainty, David Christopher Flowers
Masters Theses
Recently, ensemble modeling was applied to metabolic networks for the sake of predicting the effects of genetic manipulations on the observed phenotype of the system. The ensemble of models is generated from experimental wild-type flux data and screened using phenotypic data from gene overexpression and knockout experiments, leaving predictive models. The need for data from multiple genetic perturbation experiments is an inherent limitation to this approach. In this investigation, ensemble modeling is used alongside elementary mode analysis to attempt to predict those enzymatic perturbations that are most likely to result in an increase in a target yield and a target …
Capturing More Light: Phycobilisome Characterization For Increased Hydrogen Production Efficiency, Paul Abraham Willard
Capturing More Light: Phycobilisome Characterization For Increased Hydrogen Production Efficiency, Paul Abraham Willard
Masters Theses
Alternative energy and biofuels are a growing area of research. The demand for more and clean energy is ever increasing, but the current technology is inefficient, expensive, and incapable of meeting the demands of the current market. Hydrogen is a potential future fuel, as it is both clean and renewable, but its formation through conventional means is costly and inefficient. Photosynthesis can be utilized for the formation of hydrogen, which can then serve as a convenient and renewable biofuel. Photosynthetic hydrogen evolution is observed in vitro, but the current photosystem design is not very versatile and optimized to use …