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Feasibility Of Using The Least Square Deconvolution Approach To Resolve Three-Person Str Dna Mixture Samples, Christopher David Lucas
Feasibility Of Using The Least Square Deconvolution Approach To Resolve Three-Person Str Dna Mixture Samples, Christopher David Lucas
Masters Theses
The feasibility of using the least-square solution method to resolve three-person mixtures of short tandem repeat deoxyribonucleic acid (STR DNA) was explored in this work. Such three-person mixtures can occur in gang rapes and other violent crimes and there is currently no suitable method for resolving these mixtures. The method evaluated in this work was named LSD-3. Simulations were conducted using the MATLAB software package to evaluate the sensitivity of correct resolution to signal perturbations as a function of the relative mass ratios of the mixture contributors. Three enhancements to the LSD-3 method were investigated; locus concatenation, reference profile incorporation, …