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Full-Text Articles in Engineering
Study Level Recovery Processes Of Thorium And Several Rare Earth Elements From Monazite Ore, Makayla Hyde, Jaclyn Choate
Study Level Recovery Processes Of Thorium And Several Rare Earth Elements From Monazite Ore, Makayla Hyde, Jaclyn Choate
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Monazite ore is composed of several minerals including several rare earth element (REE) and thorium phosphates. Many past research projects have looked at the extraction of REE from monazite ore but have discarded the thorium phosphate compound as waste. Since thorium could be a possible fuel for state-of-the-art future nuclear reactors, this research focuses on a way to recover thorium from the monazite ore. The overall purpose of this research is to develop a conceptual recovery process that recovers thorium dioxide from monazite ore. In some parts of the world where uranium sources are limited; then, thorium could be used …
Protein Engineering Potential Inhibitor Of Detrimental Immune Responses, Nathaniel L. Blalock, Eric T. Boder, Liang Fang
Protein Engineering Potential Inhibitor Of Detrimental Immune Responses, Nathaniel L. Blalock, Eric T. Boder, Liang Fang
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
On the surface of immune cells, class II major histocompatibility complex proteins (MHCII) present antigenic peptides for CD4+ T cell recognition, which initiate a variety of antigen-specific immune responses such as antibody response or cytotoxic T cell activation. In people with with auto-immune diseases including but not limited to type 1 diabetes, multiple sclerosis, and rheumatoid arthritis, detrimental immune responses occur after the presentation of antigenic peptides. A single-chain, minimal MHCII (scm-MHCII) has been designed to retain its function as an antigen-presenting protein with a simplified structure that can be easily produced and manipulated in a laboratory by recombinant microbial …
Understanding Conformational Regulation Of The Integrin I-Domain For Design Of Chimeric Protein Switches, Niall Phelan Terry, Liang Fang, J Vincent Price, Eric T. Boder Dr.
Understanding Conformational Regulation Of The Integrin I-Domain For Design Of Chimeric Protein Switches, Niall Phelan Terry, Liang Fang, J Vincent Price, Eric T. Boder Dr.
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Within all complex biological processes intricate proteins are expressed to complete every niche and necessary task. Many express multiple allosterically regulated conformational states, with protein function regulated by effector molecules and other ligands. One such protein is the LFA-1 surface integrin protein and its inserted domain, the I-domain. We Isolated the I-domain for investigation of determining binding properties and understanding conformational regulations of affinity changes to its target ligand ICAM-1, for further use in chimeric protein switch design. A large change in binding affinity was found through the deletion of a sub-sequence of amino acids in I-domain known as the …
Elucidating Growth Coupling Of Metabolites In E. Coli And Characterizing Modularity., Preston N. Nicely
Elucidating Growth Coupling Of Metabolites In E. Coli And Characterizing Modularity., Preston N. Nicely
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
This project seeks to increase the efficiency of rapid engineering strain design by elucidating the functionality of a modular cell. The modular cell theory insinuates that there exists a baseline cellular framework from which cellular products can be produced by inserting a designed production module into the cell. In this study, recombinant gene cloning techniques were used to design metabolite production modules that focused on increasing the production, titer, and yield of ethanol and lactate within Escherichia coli (E. coli). An auxotrophic chassis cell was created by ModCell2 and multi-objective strain design to determine the genes necessary for deletion. The …
Adaptation And Robustness In A Chemotaxis Network, Beini Chen, Steve Abel
Adaptation And Robustness In A Chemotaxis Network, Beini Chen, Steve Abel
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
Adaptation is a behavior of biological systems in which a sustained change in input signal leads to a transient output response that returns to the pre--‐stimulated output level. Cells use adaptation to maintain sensitivity to the changes in their environment and to remain in homeostasis while the input signal is perturbed. Signaling networks in both prokaryotic and eukaryotic cells demonstrate adaptation, which is a common feature of chemotaxis, a signal transduction process that enables cells to sense chemical gradients in their extracellular environment and to adjust their movement in response. In the case of Escherichia coli, the bacteria swim in …
Effects Of System Size And Network Topology On The Bistability Of Cell Signaling Networks, Beini Chen
Effects Of System Size And Network Topology On The Bistability Of Cell Signaling Networks, Beini Chen
EURēCA: Exhibition of Undergraduate Research and Creative Achievement
No abstract provided.