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Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal
Relation Prediction Over Biomedical Knowledge Bases For Drug Repositioning, Mehmet Bakal
Theses and Dissertations--Computer Science
Identifying new potential treatment options for medical conditions that cause human disease burden is a central task of biomedical research. Since all candidate drugs cannot be tested with animal and clinical trials, in vitro approaches are first attempted to identify promising candidates. Likewise, identifying other essential relations (e.g., causation, prevention) between biomedical entities is also critical to understand biomedical processes. Hence, it is crucial to develop automated relation prediction systems that can yield plausible biomedical relations to expedite the discovery process. In this dissertation, we demonstrate three approaches to predict treatment relations between biomedical entities for the drug repositioning task …