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Engineered Material Systems For Mimicking Tissue And Disease, Margrethe Ruding
Engineered Material Systems For Mimicking Tissue And Disease, Margrethe Ruding
McKelvey School of Engineering Theses & Dissertations
This thesis comprises two studies involving design and application of soft material systems. The goal of the first study was to design, fabricate, and characterize hydrogel lattice structures with consistent, controllable, anisotropic mechanical properties. Lattices, based on four types of unit cells (cubic, diamond, vintile, and Weaire-Phelan), were printed using stereolithography (SLA) of polyethylene glycol diacrylate (PEGDA). In order to create structural anisotropy in the lattices, unit cell design files were scaled in one direction by a factor of two in each layer and then printed. The mechanical properties of the scaled lattices were measured in shear and compression and …
Longitudinal Acoustic Traps: Design, Fabrication, And Evaluation For Biological Applications, Michael Moore Binkley
Longitudinal Acoustic Traps: Design, Fabrication, And Evaluation For Biological Applications, Michael Moore Binkley
McKelvey School of Engineering Theses & Dissertations
Acoustofluidics combine ultrasonic actuation with small-volume microfluidic channels to enable precise, contactless object manipulation for a range of applications from serial chemical processing to blood component separation and single-cell analysis. Micron- to millimeter-scale vibrational waves generate reproducible pressure fields within the microfluidic channels and chambers. By exploiting the material property mismatch between a particle (polymeric and silica beads, cells, etc.) and a suspending fluid, the acoustic radiation force is used to move particles toward regions of low (nodes) or high pressure (antinodes). An understanding of these field-particle interactions is applied to design and implement complicated channel architectures for preferential segregation …