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Articles 1 - 4 of 4
Full-Text Articles in Engineering
Engineered Material Systems For Mimicking Tissue And Disease, Margrethe Ruding
Engineered Material Systems For Mimicking Tissue And Disease, Margrethe Ruding
McKelvey School of Engineering Theses & Dissertations
This thesis comprises two studies involving design and application of soft material systems. The goal of the first study was to design, fabricate, and characterize hydrogel lattice structures with consistent, controllable, anisotropic mechanical properties. Lattices, based on four types of unit cells (cubic, diamond, vintile, and Weaire-Phelan), were printed using stereolithography (SLA) of polyethylene glycol diacrylate (PEGDA). In order to create structural anisotropy in the lattices, unit cell design files were scaled in one direction by a factor of two in each layer and then printed. The mechanical properties of the scaled lattices were measured in shear and compression and …
Development Of High-Speed Photoacoustic Imaging Technology And Its Applications In Biomedical Research, Yun He
McKelvey School of Engineering Theses & Dissertations
Photoacoustic (PA) tomography (PAT) is a novel imaging modality that combines the fine lateral resolution from optical imaging and the deep penetration from ultrasonic imaging, and provides rich optical-absorption–based images. PAT has been widely used in extracting structural and functional information from both ex vivo tissue samples to in vivo animals and humans with different length scales by imaging various endogenous and exogenous contrasts at the ultraviolet to infrared spectrum. For example, hemoglobin in red blood cells is of particular interest in PAT since it is one of the dominant absorbers in tissue at the visible wavelength.The main focus of …
Longitudinal Acoustic Traps: Design, Fabrication, And Evaluation For Biological Applications, Michael Moore Binkley
Longitudinal Acoustic Traps: Design, Fabrication, And Evaluation For Biological Applications, Michael Moore Binkley
McKelvey School of Engineering Theses & Dissertations
Acoustofluidics combine ultrasonic actuation with small-volume microfluidic channels to enable precise, contactless object manipulation for a range of applications from serial chemical processing to blood component separation and single-cell analysis. Micron- to millimeter-scale vibrational waves generate reproducible pressure fields within the microfluidic channels and chambers. By exploiting the material property mismatch between a particle (polymeric and silica beads, cells, etc.) and a suspending fluid, the acoustic radiation force is used to move particles toward regions of low (nodes) or high pressure (antinodes). An understanding of these field-particle interactions is applied to design and implement complicated channel architectures for preferential segregation …
Modeling Of Swimming Cells From Nano-Scale To Micro-Scale, Yicheng Zhao
Modeling Of Swimming Cells From Nano-Scale To Micro-Scale, Yicheng Zhao
McKelvey School of Engineering Theses & Dissertations
Certain human genetic diseases -- primary ciliary dyskinesia, infertility, and hydrocephalus -- are characterized by changes in beat frequency and waveform of cilia and flagella. Chlamydomonas reinhardtii, which is a single-cell green alga about ten micrometers in diameter that swims with two flagella, serves as an excellent biological model because its flagella share the same structure and genetic background as mammalian cilia and flagella. This study uses the finite element method to investigate the behavior of C. reinhardtii swimming from nano-scale to micro-scale. At the device-level, micro-scale modeling indicates that well-designed acoustic microfluidic devices can be used to trap groups …