Family and Consumer Sciences Commons^™

The Effect Of Dietary Sulfur On The Metabolism Of Long Chain Polyunsaturated Fatty Acids, Mei Fung Chen

Doctoral Dissertations

The test hypothesis of this investigation was that methionine-supplemented diets could possibly interfere with the metabolism of polyunsaturated fatty acids, thereby altering the biosynthesis of the active metabolites, prostanoids, and the profiles of tissue phospholipids. The postulated mechanism of action for this dietary regimen would be to increase the tissue concentration of the active methyl donor, S-Adenosyl-methionine (SAM) which is also called an activated methionine. SAM is a potent inhibitor of the cycloaxygenase enzyme which is important for the synthesis of biologically active prostanoids.

The results demonstrated that liver microsomes from rats fed the methionine-supplemented diet had a statistically significant …