Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Education
Quadriceps Exercise Intolerance In Patients With Chronic Obstructive Pulmonary Disease: The Potential Role Of Altered Skeletal Muscle Mitochondrial Respiration, J. R. Gifford, Joel D. Trinity, Gwenael Layec, Ryan S. Garten, Song-Young Park, Matthew J. Rossman, Steen Larsen, Flemming Dela, Russell S. Richardson
Quadriceps Exercise Intolerance In Patients With Chronic Obstructive Pulmonary Disease: The Potential Role Of Altered Skeletal Muscle Mitochondrial Respiration, J. R. Gifford, Joel D. Trinity, Gwenael Layec, Ryan S. Garten, Song-Young Park, Matthew J. Rossman, Steen Larsen, Flemming Dela, Russell S. Richardson
Health and Kinesiology Faculty Publications
This study sought to determine if qualitative alterations in skeletal muscle mitochondrial respiration, associated with decreased mitochondrial efficiency, contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). Using permeabilized muscle fibers from the vastus lateralis of 13 patients with COPD and 12 healthy controls, complex I (CI) and complex II (CII)-driven State 3 mitochondrial respiration were measured separately (State 3:CI and State 3:CII) and in combination (State 3:CI+CII). State 2 respiration was also measured. Exercise tolerance was assessed by knee extensor exercise (KE) time to fatigue. Per milligram of muscle, State 3:CI+CII and State 3:CI were reduced …