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Gene Expression Of Components Of The Insulin/Insulin-Like Signaling Pathway In Response To Heat Stress In The Garter Snake, Thamnophis Elegans, Tonia S. Schwartz, Anne M. Bronikowski

Journal of the Iowa Academy of Science: JIAS

The insulin/insulin-like signaling (IIS) pathway is an evolutionary conserved molecular signaling pathway that regulates growth, reproduction, stress resistance, and longevity in response to nutrition and external stress. While the constituents of this pathway and their functions are relatively well understood in laboratory model animals, they have not been explored in many other organisms, with notable exceptions in the fisheries literature. We tested for the gene expression of four key components of this pathway in the garter snake (Thamnophis elegans) liver, and determine how the transcription of these components responds to heat stress. We found that the two insulin-like …